Effect of C111T polymorphism in exon 9 of the catalase gene on blood catalase activity in different types of diabetes mellitus

I. Tarnai, M. Csordás, E. Sükei, A. H. Shemirani, M. Káplár, L. Góth

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hydrogen peroxide plays a major role in the pathomechanism of diabetes mellitus and its main regulator is enzyme catalase.The blood catalase and the C111T polymorphism in exon 9 was examined in type 1, type 2 and gestational diabetes mellitus.Compared to the control group (104.7 ± 18.5MU/l) significantly decreased (p <0.001) blood catalase activities were detected in type 2 (71.2 ± 14.6MU/l), gestational (68.5 ± 12.2MU/l) diabetes mellitus and without change in type 1 (102.5 ± 26.9MU/l). The blood catalase decreased (p = 0.043) with age for type 2 diabetics and did not change (p > 0.063) for type 1, gestational diabetic patients and controls. Blood catalase showed a weak association with hemoglobin A1c for type 1 diabetic patients (r = 0.181, increasing).The mutant T allele was increased in type 1 and gestational diabetes mellitus, and CT+TT genotypes showed decreased blood catalase activity for type 1 and increased activities for type 2 diabetic patients.The C111T polymorphism may implicate a very weak effect on blood catalase activity in different types of diabetes mellitus.

Original languageEnglish
Pages (from-to)806-811
Number of pages6
JournalFree Radical Research
Volume41
Issue number7
DOIs
Publication statusPublished - 2007

Fingerprint

Medical problems
Polymorphism
Catalase
Exons
Diabetes Mellitus
Blood
Genes
Gestational Diabetes
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Hydrogen Peroxide
Hemoglobins
Alleles
Genotype
Control Groups
Enzymes

Keywords

  • Blood catalase
  • C111T polymorphism in exon 9
  • Diabetes mellitus: Type 1
  • Gestational
  • Mutation determination
  • Type 2

ASJC Scopus subject areas

  • Biochemistry

Cite this

Effect of C111T polymorphism in exon 9 of the catalase gene on blood catalase activity in different types of diabetes mellitus. / Tarnai, I.; Csordás, M.; Sükei, E.; Shemirani, A. H.; Káplár, M.; Góth, L.

In: Free Radical Research, Vol. 41, No. 7, 2007, p. 806-811.

Research output: Contribution to journalArticle

Tarnai, I. ; Csordás, M. ; Sükei, E. ; Shemirani, A. H. ; Káplár, M. ; Góth, L. / Effect of C111T polymorphism in exon 9 of the catalase gene on blood catalase activity in different types of diabetes mellitus. In: Free Radical Research. 2007 ; Vol. 41, No. 7. pp. 806-811.
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