Effect of BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs

Matyas Koltai, Istvan Lepran, Laszlo Szekeres, Isabelle Viossat, Etienne Chabrier, Pierre Braquet

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Hartley guinea-pigs were sensitized passively with antiovalbumin rabbit serum. Their isolated perfused hearts responded to the specific antigen with a marked decrease in contractile force, increase in perfusion pressure, and rhythm disturbances. All these impairments except tachycardia were decreased by BN 52021, a specific PAF-acether receptor antagonist, applied in a constant infusion before ovalbumin challenge. These findings suggest that PAF-acether plays a major role as mediator in cardiac anaphylaxis, and BN 52021 may be a valuable therapeutic agent in allergic conditions.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalEuropean Journal of Pharmacology
Volume130
Issue number1-2
DOIs
Publication statusPublished - Oct 14 1986

Fingerprint

ginkgolide B
Platelet Activating Factor
Anaphylaxis
Guinea Pigs
Ovalbumin
Tachycardia
Perfusion
Rabbits
Antigens
Pressure
Serum
Therapeutics

Keywords

  • (Guinea-pig)
  • Anaphylaxis
  • BN 52021
  • Isolated heart
  • PAF-acether antagonist
  • Passive sensitization

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effect of BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs. / Koltai, Matyas; Lepran, Istvan; Szekeres, Laszlo; Viossat, Isabelle; Chabrier, Etienne; Braquet, Pierre.

In: European Journal of Pharmacology, Vol. 130, No. 1-2, 14.10.1986, p. 133-136.

Research output: Contribution to journalArticle

Koltai, Matyas ; Lepran, Istvan ; Szekeres, Laszlo ; Viossat, Isabelle ; Chabrier, Etienne ; Braquet, Pierre. / Effect of BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs. In: European Journal of Pharmacology. 1986 ; Vol. 130, No. 1-2. pp. 133-136.
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