Effect of beta adrenergic stimulation on coronary blood flow in segmental myocardial ischaemia

A. Juhász-Nagy, G. Grosz

Research output: Contribution to journalArticle

Abstract

The coronary haemodynamic response to the administration of 0.1 μgkg-1min-1 to 1.6 μgkg-1min-1 of isoprenaline was studied in anaesthetized open chest dogs with normal coronary flow and in myocardial ischaemia induced by ligation of the anterior descending branch of the left coronary artery. Coronary blood flow was studied by the direct measurement of coronary sinus flow. Local myocardial blood flow of the ventricular area supplied by the descending coronary branch was studied by the heat clearance method. Though a slight decrease in the overall beta adrenergic dilator response of the coronary system was found after occlusion of the descending coronary branch, no significant change in the slope of the dose vs. response curves of coronary dilatation was demonstrable. Isoprenaline was found to induce local vasodilatation in the ischaemic area too, which was of the order of 50% of that recorded prior to occlusion of the descending coronary branch. It is concluded that the collateral vasculature responds to beta adrenergic impulses similarly as the coronary system.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalActa Medica Academiae Scientiarum Hungaricae
Volume30
Issue number4
Publication statusPublished - 1973

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Coronary Occlusion
Isoproterenol
Adrenergic Agents
Myocardial Ischemia
Coronary Sinus
Vasodilation
Ligation
Dilatation
Coronary Vessels
Thorax
Hot Temperature
Hemodynamics
Dogs

ASJC Scopus subject areas

  • Medicine(all)

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Effect of beta adrenergic stimulation on coronary blood flow in segmental myocardial ischaemia. / Juhász-Nagy, A.; Grosz, G.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 30, No. 4, 1973, p. 293-301.

Research output: Contribution to journalArticle

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