Effect of benzo[a]phenothiazines on natural killer cell activity of human peripheral blood mononuclear cells

I. B. Petri, E. Szekeres, I. Berek, J. Molnár, H. Sakagami, N. Motohashi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Four benzo[a]phenothiazines were investigated for their effects on antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell and blast transformation of human peripheral blood mononuclear cells (PBM). Benzo[a]phenothiazines dose-dependently suppressed the mitogen-stimulated T cell proliferation. The suppressive effect of non differentiation-inducing benzo[a]phenothiazines was higher than that of differentiation-inducing benzo[a]phenothiazines. The stimulation effect of differentiation-inducing compounds on the NK activity was reduced by removal of monocytes from the PBM. The results suggest the direct activation of monocytes (Mo) by differentiation-inducing benzo[a]phenothiazines.

Original languageEnglish
Pages (from-to)2273-2275
Number of pages3
JournalAnticancer Research
Volume13
Issue number6 A
Publication statusPublished - 1993

Fingerprint

Human Activities
Natural Killer Cells
Blood Cells
Monocytes
Lymphocyte Activation
Mitogens
Cell Proliferation
benzophenothiazine
T-Lymphocytes
Antibodies

Keywords

  • Benzo[a]phenothiazines
  • NK activity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Petri, I. B., Szekeres, E., Berek, I., Molnár, J., Sakagami, H., & Motohashi, N. (1993). Effect of benzo[a]phenothiazines on natural killer cell activity of human peripheral blood mononuclear cells. Anticancer Research, 13(6 A), 2273-2275.

Effect of benzo[a]phenothiazines on natural killer cell activity of human peripheral blood mononuclear cells. / Petri, I. B.; Szekeres, E.; Berek, I.; Molnár, J.; Sakagami, H.; Motohashi, N.

In: Anticancer Research, Vol. 13, No. 6 A, 1993, p. 2273-2275.

Research output: Contribution to journalArticle

Petri, IB, Szekeres, E, Berek, I, Molnár, J, Sakagami, H & Motohashi, N 1993, 'Effect of benzo[a]phenothiazines on natural killer cell activity of human peripheral blood mononuclear cells', Anticancer Research, vol. 13, no. 6 A, pp. 2273-2275.
Petri, I. B. ; Szekeres, E. ; Berek, I. ; Molnár, J. ; Sakagami, H. ; Motohashi, N. / Effect of benzo[a]phenothiazines on natural killer cell activity of human peripheral blood mononuclear cells. In: Anticancer Research. 1993 ; Vol. 13, No. 6 A. pp. 2273-2275.
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