The kinetic resolution of 3,5,5-trimethyl cyclohexanone (TMCH) and the asymmetric hydrogenation of isophorone (IP) were investigated both in the presence of (S)-proline (Pro) and of basic and acidic additives. The aim was to find out how the bidirectional shift from the zwitterionic form of proline can influence the reaction rates and stereoselectivities of these reactions.
- Asymmetric CC hydrogenation
- Basic additives
- Proline chiral auxiliary
ASJC Scopus subject areas
- Process Chemistry and Technology
- Physical and Theoretical Chemistry