Effect of basic and acidic additives on the (S)-proline and Pd mediated kinetic resolution of 3,5,5-trimethyl cyclohexanone and asymmetric hydrogenation of isophorone

Nóra Györffy, Antal Tungler

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The kinetic resolution of 3,5,5-trimethyl cyclohexanone (TMCH) and the asymmetric hydrogenation of isophorone (IP) were investigated both in the presence of (S)-proline (Pro) and of basic and acidic additives. The aim was to find out how the bidirectional shift from the zwitterionic form of proline can influence the reaction rates and stereoselectivities of these reactions.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalJournal of Molecular Catalysis A: Chemical
Volume336
Issue number1-2
DOIs
Publication statusPublished - Feb 14 2011

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Keywords

  • Acidic
  • Asymmetric CC hydrogenation
  • Basic additives
  • Isophorone
  • Proline chiral auxiliary

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology
  • Physical and Theoretical Chemistry

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