Effect of azidomorphine and related substances on the intestinal motility

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The inhibitory effect of azidomorphine (AM), 14 OH azidomorphine (OAM), azidocodeine (AC) in comparison to morphine, codein, hydromorphone, oxymorphone, methadone and pethidine on the propulsion of charcoal meal in mice and on the contraction of the longitudinal muscle strip of guinea pig ileum induced by electrical stimulation or polypeptides (pentagastrin, cholecystokinin) was measured and compared to their analgetic effects. While in the hot plate test the relative potencies for morphine: hydromorphone: oxymorphone: azidomorphine: 14 OH azidomorphine: azidocodeine were found to be 1:8.8:22.3:50.0:59.0:3.5 the ratios in the charcoal meal, i.e. in inhibiting propulsive contractions of the intestine were: 1:1.9:3.3:10.0:7.3:0.44, showing that the new semisynthetic derivatives are weak inhibitors of the intestinal motility. The ability of morphine derivatives to inhibit the responses of the longitudinal muscle strip to field stimulation closely correlated with their analgesic effects measured on the hot plate test.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalPharmacology
Volume12
Issue number4-5
Publication statusPublished - 1974

Fingerprint

Gastrointestinal Motility
Oxymorphone
Hydromorphone
Charcoal
Morphine
Meals
Morphine Derivatives
Pentagastrin
Meperidine
Cholecystokinin
Methadone
Muscle Contraction
Ileum
Electric Stimulation
Intestines
Analgesics
Guinea Pigs
Muscles
Peptides
azidomorphine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of azidomorphine and related substances on the intestinal motility. / Knoll, J.; Zseli, J.; Rónai, A.; Vízi, E.

In: Pharmacology, Vol. 12, No. 4-5, 1974, p. 283-289.

Research output: Contribution to journalArticle

@article{135628b930774ba1bdd962adb41c1231,
title = "Effect of azidomorphine and related substances on the intestinal motility",
abstract = "The inhibitory effect of azidomorphine (AM), 14 OH azidomorphine (OAM), azidocodeine (AC) in comparison to morphine, codein, hydromorphone, oxymorphone, methadone and pethidine on the propulsion of charcoal meal in mice and on the contraction of the longitudinal muscle strip of guinea pig ileum induced by electrical stimulation or polypeptides (pentagastrin, cholecystokinin) was measured and compared to their analgetic effects. While in the hot plate test the relative potencies for morphine: hydromorphone: oxymorphone: azidomorphine: 14 OH azidomorphine: azidocodeine were found to be 1:8.8:22.3:50.0:59.0:3.5 the ratios in the charcoal meal, i.e. in inhibiting propulsive contractions of the intestine were: 1:1.9:3.3:10.0:7.3:0.44, showing that the new semisynthetic derivatives are weak inhibitors of the intestinal motility. The ability of morphine derivatives to inhibit the responses of the longitudinal muscle strip to field stimulation closely correlated with their analgesic effects measured on the hot plate test.",
author = "J. Knoll and J. Zseli and A. R{\'o}nai and E. V{\'i}zi",
year = "1974",
language = "English",
volume = "12",
pages = "283--289",
journal = "Pharmacology",
issn = "0031-7012",
publisher = "S. Karger AG",
number = "4-5",

}

TY - JOUR

T1 - Effect of azidomorphine and related substances on the intestinal motility

AU - Knoll, J.

AU - Zseli, J.

AU - Rónai, A.

AU - Vízi, E.

PY - 1974

Y1 - 1974

N2 - The inhibitory effect of azidomorphine (AM), 14 OH azidomorphine (OAM), azidocodeine (AC) in comparison to morphine, codein, hydromorphone, oxymorphone, methadone and pethidine on the propulsion of charcoal meal in mice and on the contraction of the longitudinal muscle strip of guinea pig ileum induced by electrical stimulation or polypeptides (pentagastrin, cholecystokinin) was measured and compared to their analgetic effects. While in the hot plate test the relative potencies for morphine: hydromorphone: oxymorphone: azidomorphine: 14 OH azidomorphine: azidocodeine were found to be 1:8.8:22.3:50.0:59.0:3.5 the ratios in the charcoal meal, i.e. in inhibiting propulsive contractions of the intestine were: 1:1.9:3.3:10.0:7.3:0.44, showing that the new semisynthetic derivatives are weak inhibitors of the intestinal motility. The ability of morphine derivatives to inhibit the responses of the longitudinal muscle strip to field stimulation closely correlated with their analgesic effects measured on the hot plate test.

AB - The inhibitory effect of azidomorphine (AM), 14 OH azidomorphine (OAM), azidocodeine (AC) in comparison to morphine, codein, hydromorphone, oxymorphone, methadone and pethidine on the propulsion of charcoal meal in mice and on the contraction of the longitudinal muscle strip of guinea pig ileum induced by electrical stimulation or polypeptides (pentagastrin, cholecystokinin) was measured and compared to their analgetic effects. While in the hot plate test the relative potencies for morphine: hydromorphone: oxymorphone: azidomorphine: 14 OH azidomorphine: azidocodeine were found to be 1:8.8:22.3:50.0:59.0:3.5 the ratios in the charcoal meal, i.e. in inhibiting propulsive contractions of the intestine were: 1:1.9:3.3:10.0:7.3:0.44, showing that the new semisynthetic derivatives are weak inhibitors of the intestinal motility. The ability of morphine derivatives to inhibit the responses of the longitudinal muscle strip to field stimulation closely correlated with their analgesic effects measured on the hot plate test.

UR - http://www.scopus.com/inward/record.url?scp=0016312680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016312680&partnerID=8YFLogxK

M3 - Article

C2 - 4471352

AN - SCOPUS:0016312680

VL - 12

SP - 283

EP - 289

JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

IS - 4-5

ER -