Effect of atropine and cimetidine combinations on pentagastrin stimulated maximal gastric acid secretion in man.

F. Tárnok, G. Mózsik

Research output: Contribution to journalArticle

Abstract

Recently it has been reported that anticholinergics were able to increase the inhibitory effect on gastric secretion of specific histamine H2-receptor antagonists. The aim of the present study was to determine the degree of increased inhibition of gastric acid secretion and also to introduce an exact method for measuring the gastric acid output. Maximal gastric acid secretion provoked by continuous pentagastrin infusion 3.4-4.0 micrograms X kg-1 h-1) was dose-dependently inhibited by intravenous (i.v.) atropine (0.002; 0.003; 0.004 mg X kg-1) and cimetidine (1.0; 1.5; 2.0 mg X kg-1). A potentiated synergism was observed on the simultaneous administration of atropine and cimetidine, suggesting the good effect of a low dose combination of atropine and cimetidine in the therapy of peptic ulcer.

Original languageEnglish
Pages (from-to)359-364
Number of pages6
JournalActa Medica Hungarica
Volume43
Issue number4
Publication statusPublished - 1986

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Pentagastrin
Gastric Acid
Cimetidine
Atropine
Histamine H2 Antagonists
Cholinergic Antagonists
Peptic Ulcer
Stomach
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Effect of atropine and cimetidine combinations on pentagastrin stimulated maximal gastric acid secretion in man. / Tárnok, F.; Mózsik, G.

In: Acta Medica Hungarica, Vol. 43, No. 4, 1986, p. 359-364.

Research output: Contribution to journalArticle

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