Effect of atrial natriuretic peptide on DOPA potentiation in mice

Amelia Bidzseranova, Jony Gueron, Gábor Tóth, Botond Penke, Gyula Telegdy

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Abstract

The effect of rat atrial natriuretic peptide (ANP1-28) on the pargyline-DOPA potentiation test was studied following its administration into the lateral brain ventricle in mice. Thirty minutes after pargyline pretreatment, three doses of ANP (200, 500, or 1,000 ng/mouse) were administered simultaneously with DOPA and animals were then observed for 2 h. ANP in doses of 500 and 1,000 ng markedly enhanced the effect of DOPA. The maximum intensity of the effect was registered 30-45 min following administration of the peptide. The data suggest that ANP might be regarded as a dopaminergic-modulating agent in the CNS.

Original languageEnglish
Pages (from-to)767-768
Number of pages2
JournalBrain Research Bulletin
Volume28
Issue number5
DOIs
Publication statusPublished - May 1992

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Keywords

  • Atrial natriuretic peptide
  • DOPA potentiation
  • Pargyline

ASJC Scopus subject areas

  • Neuroscience(all)

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