Effect of antibiotic treatment on bacterial attachment to a DePuy Enduron™ orthopedic implant

Ildikó Kustos, Tamás Kustos, F. Kilár, Gábor Rappai, Béla Kocsis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The increasing incidence of bacterial infections in orthopedic surgery might be related to the increasing application of artificial devices. In most cases, bacteria multiply on the surface of implants in biofilms. Poor penetration of antibiotics, frequent necessity of prosthesis removal, chronic processes and financial costs emphasize the significance of preventive measures. Method: Adhesion of bacterial strains (two Staphylococcus aureus, two coagulase-negative staphylococci and two Pseudomonas aeruginosa strains isolated from orthopedic patients' wounds) to the surface of a polyethylene cup was investigated using an ultrasonic method. Results were compared to the adhesive ability of three Hungarian standard strains. The effect of antibiotic treatment (cefuroxime, cefotaxime, amoxicillin with clavulanic acid and amikacin) has been examined. Results: The staphylococcal strains showed significantly higher adhesive ability than Pseudomonas strains. Antibiotic treatment significantly reduced the attachment of bacteria. The higher the concentration of the antibiotics, the higher was the decrease in bacterial adhesion. Conclusions: Antibiotic prophylaxis was proven to be effective against bacterial adhesion, and, if applied at the proper time at the highest tolerable dose, it might prevent the formation of biofilms.

Original languageEnglish
Pages (from-to)286-290
Number of pages5
JournalChemotherapy
Volume51
Issue number5
DOIs
Publication statusPublished - Aug 2005

Fingerprint

Methyclothiazide
Bacterial Adhesion
Orthopedics
Anti-Bacterial Agents
Biofilms
Adhesives
Bacteria
Amoxicillin-Potassium Clavulanate Combination
Cefuroxime
Amikacin
Antibiotic Prophylaxis
Cefotaxime
Coagulase
Polyethylene
Therapeutics
Pseudomonas
Staphylococcus
Bacterial Infections
Ultrasonics
Pseudomonas aeruginosa

Keywords

  • Antibiotic treatment
  • Bacterial attachment
  • Infections
  • Orthopedic surgery
  • Polyethylene implant
  • Prostheses

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Effect of antibiotic treatment on bacterial attachment to a DePuy Enduron™ orthopedic implant. / Kustos, Ildikó; Kustos, Tamás; Kilár, F.; Rappai, Gábor; Kocsis, Béla.

In: Chemotherapy, Vol. 51, No. 5, 08.2005, p. 286-290.

Research output: Contribution to journalArticle

Kustos, Ildikó ; Kustos, Tamás ; Kilár, F. ; Rappai, Gábor ; Kocsis, Béla. / Effect of antibiotic treatment on bacterial attachment to a DePuy Enduron™ orthopedic implant. In: Chemotherapy. 2005 ; Vol. 51, No. 5. pp. 286-290.
@article{1d1c585704e8457ab28c4b623b9cd661,
title = "Effect of antibiotic treatment on bacterial attachment to a DePuy Enduron™ orthopedic implant",
abstract = "Background: The increasing incidence of bacterial infections in orthopedic surgery might be related to the increasing application of artificial devices. In most cases, bacteria multiply on the surface of implants in biofilms. Poor penetration of antibiotics, frequent necessity of prosthesis removal, chronic processes and financial costs emphasize the significance of preventive measures. Method: Adhesion of bacterial strains (two Staphylococcus aureus, two coagulase-negative staphylococci and two Pseudomonas aeruginosa strains isolated from orthopedic patients' wounds) to the surface of a polyethylene cup was investigated using an ultrasonic method. Results were compared to the adhesive ability of three Hungarian standard strains. The effect of antibiotic treatment (cefuroxime, cefotaxime, amoxicillin with clavulanic acid and amikacin) has been examined. Results: The staphylococcal strains showed significantly higher adhesive ability than Pseudomonas strains. Antibiotic treatment significantly reduced the attachment of bacteria. The higher the concentration of the antibiotics, the higher was the decrease in bacterial adhesion. Conclusions: Antibiotic prophylaxis was proven to be effective against bacterial adhesion, and, if applied at the proper time at the highest tolerable dose, it might prevent the formation of biofilms.",
keywords = "Antibiotic treatment, Bacterial attachment, Infections, Orthopedic surgery, Polyethylene implant, Prostheses",
author = "Ildik{\'o} Kustos and Tam{\'a}s Kustos and F. Kil{\'a}r and G{\'a}bor Rappai and B{\'e}la Kocsis",
year = "2005",
month = "8",
doi = "10.1159/000087256",
language = "English",
volume = "51",
pages = "286--290",
journal = "Chemotherapy",
issn = "0009-3157",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Effect of antibiotic treatment on bacterial attachment to a DePuy Enduron™ orthopedic implant

AU - Kustos, Ildikó

AU - Kustos, Tamás

AU - Kilár, F.

AU - Rappai, Gábor

AU - Kocsis, Béla

PY - 2005/8

Y1 - 2005/8

N2 - Background: The increasing incidence of bacterial infections in orthopedic surgery might be related to the increasing application of artificial devices. In most cases, bacteria multiply on the surface of implants in biofilms. Poor penetration of antibiotics, frequent necessity of prosthesis removal, chronic processes and financial costs emphasize the significance of preventive measures. Method: Adhesion of bacterial strains (two Staphylococcus aureus, two coagulase-negative staphylococci and two Pseudomonas aeruginosa strains isolated from orthopedic patients' wounds) to the surface of a polyethylene cup was investigated using an ultrasonic method. Results were compared to the adhesive ability of three Hungarian standard strains. The effect of antibiotic treatment (cefuroxime, cefotaxime, amoxicillin with clavulanic acid and amikacin) has been examined. Results: The staphylococcal strains showed significantly higher adhesive ability than Pseudomonas strains. Antibiotic treatment significantly reduced the attachment of bacteria. The higher the concentration of the antibiotics, the higher was the decrease in bacterial adhesion. Conclusions: Antibiotic prophylaxis was proven to be effective against bacterial adhesion, and, if applied at the proper time at the highest tolerable dose, it might prevent the formation of biofilms.

AB - Background: The increasing incidence of bacterial infections in orthopedic surgery might be related to the increasing application of artificial devices. In most cases, bacteria multiply on the surface of implants in biofilms. Poor penetration of antibiotics, frequent necessity of prosthesis removal, chronic processes and financial costs emphasize the significance of preventive measures. Method: Adhesion of bacterial strains (two Staphylococcus aureus, two coagulase-negative staphylococci and two Pseudomonas aeruginosa strains isolated from orthopedic patients' wounds) to the surface of a polyethylene cup was investigated using an ultrasonic method. Results were compared to the adhesive ability of three Hungarian standard strains. The effect of antibiotic treatment (cefuroxime, cefotaxime, amoxicillin with clavulanic acid and amikacin) has been examined. Results: The staphylococcal strains showed significantly higher adhesive ability than Pseudomonas strains. Antibiotic treatment significantly reduced the attachment of bacteria. The higher the concentration of the antibiotics, the higher was the decrease in bacterial adhesion. Conclusions: Antibiotic prophylaxis was proven to be effective against bacterial adhesion, and, if applied at the proper time at the highest tolerable dose, it might prevent the formation of biofilms.

KW - Antibiotic treatment

KW - Bacterial attachment

KW - Infections

KW - Orthopedic surgery

KW - Polyethylene implant

KW - Prostheses

UR - http://www.scopus.com/inward/record.url?scp=23944500792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944500792&partnerID=8YFLogxK

U2 - 10.1159/000087256

DO - 10.1159/000087256

M3 - Article

C2 - 16088126

AN - SCOPUS:23944500792

VL - 51

SP - 286

EP - 290

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

IS - 5

ER -