Modifizierung der primärabstossung xenogener nierentransplantate durch anti-donor-lymphozyten-globulin

Translated title of the contribution: Effect of anti-donor lymphocyte globulin on renal xenograft survival

C. H. Prange, M. Kessler, D. Bach

Research output: Contribution to journalArticle

Abstract

This paper reports about experimental xenografting of kidneys in closely related species (fox - dog) modifying primary graft rejection by treatment of the recipients with anti-donor lymphocyte globulin (ADLG). In respect of the phylogenetic constellations, ADLG contains lymphocytotoxic and hemagglutinating antibodies reactive in vitro with lymphocytes and erythrocytes of foxes as well as of dogs. Furthermore, donor species-specific papain-separated lymphocyte antigen is capable of reducing cytotoxicity of ADLG by adsorption of its lymphocytotoxic antibodies. In vivo ADLG, used as single therapy, has an immunosuppressive effect on kidney graft survival, which results in significant prolongation of mean survival time (9.6 ± 1.5 days, n = 5).

Original languageGerman
Pages (from-to)105-111
Number of pages7
JournalUrologia Internationalis
Volume35
Issue number2
DOIs
Publication statusPublished - 1980

Fingerprint

Globulins
Heterografts
Lymphocytes
Kidney
Antilymphocyte Serum
Dogs
Heterologous Transplantation
Papain
Graft Rejection
Graft Survival
Immunosuppressive Agents
Adsorption
Erythrocytes
Antigens

Keywords

  • Anti-donor lymphocyte globulin
  • Graft rejection
  • Immunosuppression
  • Xenografting

ASJC Scopus subject areas

  • Urology

Cite this

Modifizierung der primärabstossung xenogener nierentransplantate durch anti-donor-lymphozyten-globulin. / Prange, C. H.; Kessler, M.; Bach, D.

In: Urologia Internationalis, Vol. 35, No. 2, 1980, p. 105-111.

Research output: Contribution to journalArticle

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