Effect of angiotensin II on macrophage functions

G. Foris, B. Dezső, G. A. Medgyesi, G. Füst

Research output: Contribution to journalArticle

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Abstract

Angiotensin II (At II) has been shown to inhibit in vitro the IgG2a-mediated rosette formation of 51Cr-sheep red blood cells (SRBC) by provoked peritoneal macrophages (PM) at 10-5-10-6 M concentrations. The decreased rosette formation was associated with an increased phagocytosis. It was found that the enhanced rosette formation at 10-7 M hormone concentration was followed by diminished phagocytosis via Fcγ receptors (R). Processes mediated through FcμR were affected only after incubation with 10-5 M of At II. The attachment and subsequent phagocytosis through C3bR was markedly enhanced by At II in a dose-dependent way. Thus, the relative phagocytosis (RP) through both FcRs was significantly enhanced by 10-5, i.e. by 10-5-10-6 M of At II, but lowered at 10-7 M hormone concentration. In addition, there was no RP enhancing effect of At II after preincubation with 10-5 M of indomethacin (IM), indicating the significance of prostaglandins (PG) in the hormone effect. The medium containing 5 mM of EGTA diminished both the RP enhancing and inhibiting effects of At II. The RP mediated by C3b was not affected by At II, IM or EGTA. The intracellular killing capability, measured by chromium release from Candida albicans, was not altered or even slightly diminished after At II treatment of PMs.

Original languageEnglish
Pages (from-to)529-535
Number of pages7
JournalImmunology
Volume48
Issue number3
Publication statusPublished - 1983

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Angiotensin II
Phagocytosis
Macrophages
Rosette Formation
Egtazic Acid
Hormones
Indomethacin
Fc Receptors
Peritoneal Macrophages
Chromium
Candida albicans
Prostaglandins
Sheep
Erythrocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Effect of angiotensin II on macrophage functions. / Foris, G.; Dezső, B.; Medgyesi, G. A.; Füst, G.

In: Immunology, Vol. 48, No. 3, 1983, p. 529-535.

Research output: Contribution to journalArticle

Foris, G, Dezső, B, Medgyesi, GA & Füst, G 1983, 'Effect of angiotensin II on macrophage functions', Immunology, vol. 48, no. 3, pp. 529-535.
Foris, G. ; Dezső, B. ; Medgyesi, G. A. ; Füst, G. / Effect of angiotensin II on macrophage functions. In: Immunology. 1983 ; Vol. 48, No. 3. pp. 529-535.
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AB - Angiotensin II (At II) has been shown to inhibit in vitro the IgG2a-mediated rosette formation of 51Cr-sheep red blood cells (SRBC) by provoked peritoneal macrophages (PM) at 10-5-10-6 M concentrations. The decreased rosette formation was associated with an increased phagocytosis. It was found that the enhanced rosette formation at 10-7 M hormone concentration was followed by diminished phagocytosis via Fcγ receptors (R). Processes mediated through FcμR were affected only after incubation with 10-5 M of At II. The attachment and subsequent phagocytosis through C3bR was markedly enhanced by At II in a dose-dependent way. Thus, the relative phagocytosis (RP) through both FcRs was significantly enhanced by 10-5, i.e. by 10-5-10-6 M of At II, but lowered at 10-7 M hormone concentration. In addition, there was no RP enhancing effect of At II after preincubation with 10-5 M of indomethacin (IM), indicating the significance of prostaglandins (PG) in the hormone effect. The medium containing 5 mM of EGTA diminished both the RP enhancing and inhibiting effects of At II. The RP mediated by C3b was not affected by At II, IM or EGTA. The intracellular killing capability, measured by chromium release from Candida albicans, was not altered or even slightly diminished after At II treatment of PMs.

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