Effect of angiotensin-converting enzyme inhibitors captopril and enalapril on cAMP content of specific brain areas in spontaneously hypertensive rats

H. Geiger, U. Bahner, M. Palkóvits, A. Heidland

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. The influence of two angiotensin-converting enzyme inhibitors, captopril and enalapril, on the cAMP content of microdissected brain areas was examined in spontaneously hypertensive rats. Both drugs depleted systolic arterial blood pressure significantly. 2. Captopril and enalapril increased the level of cAMP in catecholaminergic cell groups in the lower brain-stem. Captopril was more effective in the substantia nigra, while enalapril treatment resulted in high cAMP levels in the ventrolateral medulla oblongata (A1 catecholaminergic cell group). 3. Both drugs, especially captopril, depleted cAMP content in the cingulate cortex. 4. No changes in cAMP levels were measured in the primary baroreceptor centre (nucleus of the solitary tract) following either captopril or enalapril treatment.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume14
Issue number4
Publication statusPublished - 1987

Fingerprint

Enalapril
Captopril
Inbred SHR Rats
Angiotensin-Converting Enzyme Inhibitors
Brain
Medulla Oblongata
Pressoreceptors
Solitary Nucleus
Gyrus Cinguli
Substantia Nigra
Pharmaceutical Preparations
Brain Stem
Arterial Pressure

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "1. The influence of two angiotensin-converting enzyme inhibitors, captopril and enalapril, on the cAMP content of microdissected brain areas was examined in spontaneously hypertensive rats. Both drugs depleted systolic arterial blood pressure significantly. 2. Captopril and enalapril increased the level of cAMP in catecholaminergic cell groups in the lower brain-stem. Captopril was more effective in the substantia nigra, while enalapril treatment resulted in high cAMP levels in the ventrolateral medulla oblongata (A1 catecholaminergic cell group). 3. Both drugs, especially captopril, depleted cAMP content in the cingulate cortex. 4. No changes in cAMP levels were measured in the primary baroreceptor centre (nucleus of the solitary tract) following either captopril or enalapril treatment.",
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T1 - Effect of angiotensin-converting enzyme inhibitors captopril and enalapril on cAMP content of specific brain areas in spontaneously hypertensive rats

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AU - Palkóvits, M.

AU - Heidland, A.

PY - 1987

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AB - 1. The influence of two angiotensin-converting enzyme inhibitors, captopril and enalapril, on the cAMP content of microdissected brain areas was examined in spontaneously hypertensive rats. Both drugs depleted systolic arterial blood pressure significantly. 2. Captopril and enalapril increased the level of cAMP in catecholaminergic cell groups in the lower brain-stem. Captopril was more effective in the substantia nigra, while enalapril treatment resulted in high cAMP levels in the ventrolateral medulla oblongata (A1 catecholaminergic cell group). 3. Both drugs, especially captopril, depleted cAMP content in the cingulate cortex. 4. No changes in cAMP levels were measured in the primary baroreceptor centre (nucleus of the solitary tract) following either captopril or enalapril treatment.

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