Effect of anaesthetics on the release of beta-endorphin-immunoreactivity in rat plasma

Maria Dolores Ramirez-Gonzalez, I. Barna, Victor M. Wiegant, Wybren de Jong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Analgesia and anaesthesia produced by fentanyl, urethane and ether, but not pentobarbital, occured concomitantly with an increase in the concentration of plasma beta-endorphin like immunoreactivity (BEIR), probably of pituitary origin. This increase was not associated with significant changes in pituitary or brainstem beta-endorphin content. Pretreatment with naloxone caused a reduction in plasma BEIR increase following HypnormR, ether and urethane; and in the analgesia following HypnormR and urethane. Pentobarbital, alone or in combination with naloxone, did not increase the concentration of plasma beta-endorphin. These results may indicate participation of endogenous opioids in the mechanism of action of urethane.

Original languageEnglish
Pages (from-to)1371-1377
Number of pages7
JournalLife Sciences
Volume48
Issue number14
DOIs
Publication statusPublished - 1991

Fingerprint

beta-Endorphin
Urethane
Anesthetics
Rats
Plasmas
Pentobarbital
Naloxone
Ether
Anesthesia and Analgesia
Fentanyl
Analgesia
Opioid Analgesics
Brain Stem

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of anaesthetics on the release of beta-endorphin-immunoreactivity in rat plasma. / Ramirez-Gonzalez, Maria Dolores; Barna, I.; Wiegant, Victor M.; de Jong, Wybren.

In: Life Sciences, Vol. 48, No. 14, 1991, p. 1371-1377.

Research output: Contribution to journalArticle

Ramirez-Gonzalez, Maria Dolores ; Barna, I. ; Wiegant, Victor M. ; de Jong, Wybren. / Effect of anaesthetics on the release of beta-endorphin-immunoreactivity in rat plasma. In: Life Sciences. 1991 ; Vol. 48, No. 14. pp. 1371-1377.
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