Effect of anaesthetics on the release of beta-endorphin-immunoreactivity in rat plasma

Maria Dolores Ramirez-Gonzalez, Istvan Barna, Victor M. Wiegant, Wybren de Jong

Research output: Contribution to journalArticle

7 Citations (Scopus)


Analgesia and anaesthesia produced by fentanyl, urethane and ether, but not pentobarbital, occured concomitantly with an increase in the concentration of plasma beta-endorphin like immunoreactivity (BEIR), probably of pituitary origin. This increase was not associated with significant changes in pituitary or brainstem beta-endorphin content. Pretreatment with naloxone caused a reduction in plasma BEIR increase following HypnormR, ether and urethane; and in the analgesia following HypnormR and urethane. Pentobarbital, alone or in combination with naloxone, did not increase the concentration of plasma beta-endorphin. These results may indicate participation of endogenous opioids in the mechanism of action of urethane.

Original languageEnglish
Pages (from-to)1371-1377
Number of pages7
JournalLife Sciences
Issue number14
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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