Effect of anaesthetics on the release of beta-endorphin-immunoreactivity in rat plasma

Maria Dolores Ramirez-Gonzalez, Istvan Barna, Victor M. Wiegant, Wybren de Jong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Analgesia and anaesthesia produced by fentanyl, urethane and ether, but not pentobarbital, occured concomitantly with an increase in the concentration of plasma beta-endorphin like immunoreactivity (BEIR), probably of pituitary origin. This increase was not associated with significant changes in pituitary or brainstem beta-endorphin content. Pretreatment with naloxone caused a reduction in plasma BEIR increase following HypnormR, ether and urethane; and in the analgesia following HypnormR and urethane. Pentobarbital, alone or in combination with naloxone, did not increase the concentration of plasma beta-endorphin. These results may indicate participation of endogenous opioids in the mechanism of action of urethane.

Original languageEnglish
Pages (from-to)1371-1377
Number of pages7
JournalLife Sciences
Volume48
Issue number14
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Effect of anaesthetics on the release of beta-endorphin-immunoreactivity in rat plasma'. Together they form a unique fingerprint.

  • Cite this