Antibiotikum-kombináció hatása a Lyme-kórt okozó Borrelia burgdorferi szaporodására.

Translated title of the contribution: Effect of an antibiotic combination on the propagation of Borrelia burgdorferi, causative agent of Lyme disease

A. Lakos, G. Nagy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of combined antibiotics (pefloxacin-doxycycline and pefloxacin-ceftriaxone) were tested on the most prevalent European Lyme spirochete species, Borrelia garinii by checkerboard dilution. The influence was judged both microscopically and by the measurement of the pH of the culture medium on the 5th day after inoculation. Borreliae propagated quite well at the concentration of 4 mg/l pefloxacin but the motility and the metabolism of the spirochete injured. Neither synergetic nor additive effect of the combination could be registered. Surprisingly, the pefloxacin at a concentration less than 4 mg/l activated both the propagation and the metabolism of borreliae, showing a clear antagonistic effect with doxycycline and ceftriaxone. Unless well-controlled animal model will prove the contrary, quinolones neither alone nor in combination should be used in Lyme borreliosis.

Original languageHungarian
Pages (from-to)1529-1532
Number of pages4
JournalOrvosi Hetilap
Volume140
Issue number27
Publication statusPublished - Jul 4 1999

Fingerprint

Pefloxacin
Borrelia burgdorferi
Lyme Disease
Anti-Bacterial Agents
Borrelia
Spirochaetales
Ceftriaxone
Doxycycline
Borrelia burgdorferi Group
Quinolones
Culture Media
Animal Models

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antibiotikum-kombináció hatása a Lyme-kórt okozó Borrelia burgdorferi szaporodására. / Lakos, A.; Nagy, G.

In: Orvosi Hetilap, Vol. 140, No. 27, 04.07.1999, p. 1529-1532.

Research output: Contribution to journalArticle

@article{847357229ec140d699496ea9c6280141,
title = "Antibiotikum-kombin{\'a}ci{\'o} hat{\'a}sa a Lyme-k{\'o}rt okoz{\'o} Borrelia burgdorferi szaporod{\'a}s{\'a}ra.",
abstract = "The effects of combined antibiotics (pefloxacin-doxycycline and pefloxacin-ceftriaxone) were tested on the most prevalent European Lyme spirochete species, Borrelia garinii by checkerboard dilution. The influence was judged both microscopically and by the measurement of the pH of the culture medium on the 5th day after inoculation. Borreliae propagated quite well at the concentration of 4 mg/l pefloxacin but the motility and the metabolism of the spirochete injured. Neither synergetic nor additive effect of the combination could be registered. Surprisingly, the pefloxacin at a concentration less than 4 mg/l activated both the propagation and the metabolism of borreliae, showing a clear antagonistic effect with doxycycline and ceftriaxone. Unless well-controlled animal model will prove the contrary, quinolones neither alone nor in combination should be used in Lyme borreliosis.",
author = "A. Lakos and G. Nagy",
year = "1999",
month = "7",
day = "4",
language = "Hungarian",
volume = "140",
pages = "1529--1532",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "27",

}

TY - JOUR

T1 - Antibiotikum-kombináció hatása a Lyme-kórt okozó Borrelia burgdorferi szaporodására.

AU - Lakos, A.

AU - Nagy, G.

PY - 1999/7/4

Y1 - 1999/7/4

N2 - The effects of combined antibiotics (pefloxacin-doxycycline and pefloxacin-ceftriaxone) were tested on the most prevalent European Lyme spirochete species, Borrelia garinii by checkerboard dilution. The influence was judged both microscopically and by the measurement of the pH of the culture medium on the 5th day after inoculation. Borreliae propagated quite well at the concentration of 4 mg/l pefloxacin but the motility and the metabolism of the spirochete injured. Neither synergetic nor additive effect of the combination could be registered. Surprisingly, the pefloxacin at a concentration less than 4 mg/l activated both the propagation and the metabolism of borreliae, showing a clear antagonistic effect with doxycycline and ceftriaxone. Unless well-controlled animal model will prove the contrary, quinolones neither alone nor in combination should be used in Lyme borreliosis.

AB - The effects of combined antibiotics (pefloxacin-doxycycline and pefloxacin-ceftriaxone) were tested on the most prevalent European Lyme spirochete species, Borrelia garinii by checkerboard dilution. The influence was judged both microscopically and by the measurement of the pH of the culture medium on the 5th day after inoculation. Borreliae propagated quite well at the concentration of 4 mg/l pefloxacin but the motility and the metabolism of the spirochete injured. Neither synergetic nor additive effect of the combination could be registered. Surprisingly, the pefloxacin at a concentration less than 4 mg/l activated both the propagation and the metabolism of borreliae, showing a clear antagonistic effect with doxycycline and ceftriaxone. Unless well-controlled animal model will prove the contrary, quinolones neither alone nor in combination should be used in Lyme borreliosis.

UR - http://www.scopus.com/inward/record.url?scp=17644434295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17644434295&partnerID=8YFLogxK

M3 - Article

VL - 140

SP - 1529

EP - 1532

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 27

ER -