Effect of an anti-substance P serum on prolactin and gonadotropins in hyperprolactinemic rats

L. Debeljuk, M. Lasaga, J. Horvath, B. H. Duvilanski, A. Seilicovich, M. del

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19 Citations (Scopus)

Abstract

The effects of the acute injection of a rabbit anti-substance P serum (ASPS) were studied in normal rats and rats with hyperprolactinemia induced by 5-hydroxytryptophan and estradiol given as a short or chronic treatment. The anti-substance P serum decreased the release of prolactin induced by 5-hydroxytryptophan when this serotonin precursor was injected 24 h, but not 1 h, after the administration of the antiserum. ASPS reduced the hyperprolactinemia induced by short and chronic treatment with estradiol in castrated rats. This effect was observed 24 h after the injection of the antiserum. On the other hand, the injection of ASPS induced a significant decrease in LH levels in serum of intact male rats injected with 5-hydroxytryptophan 24 h after ASPS, and in castrated rats treated with short-term and chronic administration of estradiol, 24 h after the injection of the antiserum. These results suggest that substance P may have a role in the control of prolactin secretion and could play a part in the hyperprolactinemic effects of estradiol. On the other hand, substance P, under certain circumstances, may stimulate LH release.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalRegulatory Peptides
Volume19
Issue number1-2
DOIs
Publication statusPublished - Oct 1987

Keywords

  • Anterior pituitary
  • Anti-substance P serum
  • Estrogen
  • Gonadotropin
  • Prolactin
  • Substance P

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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