Effect of amine functionalization of spherical MCM-41 and SBA-15 on controlled drug release

A. Szegedi, M. Popova, I. Goshev, J. Mihály

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

MCM-41 and SBA-15 silica materials with spherical morphology and different particle sizes were synthesized and modified by post-synthesis method with 3-aminopropyltriethoxysilane (APTES). A comparative study of the adsorption and release of a model drug, ibuprofen, were carried out. The modified and drug loaded mesoporous materials were characterized by XRD, TEM, N2 physisorption, thermal analysis, elemental analysis and FT-IR spectroscopy. Surface modification with amino groups resulted in high degree of ibuprofen loading and slow rate of release for MCM-41, whereas it was the opposite for SBA-15. The adsorbed drug content and the delivery rate can be predetermined by the choice of mesoporous material with the appropriate structural characteristics and surface functionality.

Original languageEnglish
Pages (from-to)1201-1207
Number of pages7
JournalJournal of Solid State Chemistry
Volume184
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

Mesoporous materials
Multicarrier modulation
Amines
amines
drugs
Ibuprofen
Physisorption
Pharmaceutical Preparations
Thermoanalysis
Surface treatment
Infrared spectroscopy
loading rate
Particle size
Silica
Transmission electron microscopy
Adsorption
Silicon Dioxide
delivery
thermal analysis
Chemical analysis

Keywords

  • Drug release
  • Ibuprofen
  • Mesoporous silica

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry

Cite this

Effect of amine functionalization of spherical MCM-41 and SBA-15 on controlled drug release. / Szegedi, A.; Popova, M.; Goshev, I.; Mihály, J.

In: Journal of Solid State Chemistry, Vol. 184, No. 5, 05.2011, p. 1201-1207.

Research output: Contribution to journalArticle

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