Effect of alpha-pinene on the mixed function microsomal oxidase system in the rat.

A. Pap, F. Szarvas

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The microsomal fraction of the liver was studied for protein and cytochrome P 450 contents as well as for aminopyrine N-demethylase and aniline hydroxylase activity and for its butylisocyanide spectrum under the effect of alpha-pinene treatment. A moderate increase was found in the amount of microsomal protein and cytochrome P 450, a marked increase in the metabolism of both aminopyrine (substrate of type I) and aniline (substrate of type II), together with an increase in the butylisocyanide-absorption maxima of both haemoproteins involved in the reaction. Thus, alpha-pinene is a broad-spectrum enzyme inductor of the phenobarbital type, with certain quantitative differences.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalActa Medica Academiae Scientiarum Hungaricae
Volume33
Issue number4
Publication statusPublished - 1976

Fingerprint

Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Aminopyrine N-Demethylase
Aniline Hydroxylase
Aminopyrine
Phenobarbital
Proteins
Liver
Enzymes
alpha-pinene
aniline

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of alpha-pinene on the mixed function microsomal oxidase system in the rat. / Pap, A.; Szarvas, F.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 33, No. 4, 1976, p. 379-385.

Research output: Contribution to journalArticle

@article{96ce234f88764335bb4ab36da739169f,
title = "Effect of alpha-pinene on the mixed function microsomal oxidase system in the rat.",
abstract = "The microsomal fraction of the liver was studied for protein and cytochrome P 450 contents as well as for aminopyrine N-demethylase and aniline hydroxylase activity and for its butylisocyanide spectrum under the effect of alpha-pinene treatment. A moderate increase was found in the amount of microsomal protein and cytochrome P 450, a marked increase in the metabolism of both aminopyrine (substrate of type I) and aniline (substrate of type II), together with an increase in the butylisocyanide-absorption maxima of both haemoproteins involved in the reaction. Thus, alpha-pinene is a broad-spectrum enzyme inductor of the phenobarbital type, with certain quantitative differences.",
author = "A. Pap and F. Szarvas",
year = "1976",
language = "English",
volume = "33",
pages = "379--385",
journal = "Acta Medica Academiae Scientiarum Hungaricae",
issn = "0001-5989",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - Effect of alpha-pinene on the mixed function microsomal oxidase system in the rat.

AU - Pap, A.

AU - Szarvas, F.

PY - 1976

Y1 - 1976

N2 - The microsomal fraction of the liver was studied for protein and cytochrome P 450 contents as well as for aminopyrine N-demethylase and aniline hydroxylase activity and for its butylisocyanide spectrum under the effect of alpha-pinene treatment. A moderate increase was found in the amount of microsomal protein and cytochrome P 450, a marked increase in the metabolism of both aminopyrine (substrate of type I) and aniline (substrate of type II), together with an increase in the butylisocyanide-absorption maxima of both haemoproteins involved in the reaction. Thus, alpha-pinene is a broad-spectrum enzyme inductor of the phenobarbital type, with certain quantitative differences.

AB - The microsomal fraction of the liver was studied for protein and cytochrome P 450 contents as well as for aminopyrine N-demethylase and aniline hydroxylase activity and for its butylisocyanide spectrum under the effect of alpha-pinene treatment. A moderate increase was found in the amount of microsomal protein and cytochrome P 450, a marked increase in the metabolism of both aminopyrine (substrate of type I) and aniline (substrate of type II), together with an increase in the butylisocyanide-absorption maxima of both haemoproteins involved in the reaction. Thus, alpha-pinene is a broad-spectrum enzyme inductor of the phenobarbital type, with certain quantitative differences.

UR - http://www.scopus.com/inward/record.url?scp=0017204358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017204358&partnerID=8YFLogxK

M3 - Article

C2 - 1032243

AN - SCOPUS:0017204358

VL - 33

SP - 379

EP - 385

JO - Acta Medica Academiae Scientiarum Hungaricae

JF - Acta Medica Academiae Scientiarum Hungaricae

SN - 0001-5989

IS - 4

ER -