Bilateral destruction of the ventromedial hypothalamic area /VMH/ of rats produced hyperphagia and extreme obesity. Many investigators have reported a wide variety of metabolic alterations following lesions in the VMH. The plasma IRI level has been found to be considerably elevated after VMH destruction even when hyperphagia was prevented. However, hyperphagia was interpreted as the consequence of the elevated insulin level. These observations raise the idea that there must therefore be some direct relationship between the VMH and the insulin secretion mechanism. The problem was approached up to this time from the point of view of the hypothalamus. In the present study the authors tested the effect of the destruction of insulin producing beta cells by alloxan on the RNA synthesis activity in the VMH cells using autoradiograpjy in light and electron microscopy.
|Number of pages||16|
|Publication status||Published - Jan 1 1976|
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