Effect of ageing on colonic mucosal regeneration

F. Sípos, Katalin Leiszter, Z. Tulassay

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the epithelium. On the one hand, age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation, which results in epithelial damage. On the other hand, the altered migration and function of regenerative stem cells, the age-related methylation of mucosal healing-associated genes, together with the alterations of growth factor signaling with age, may be involved in delayed mucosal regeneration. The connections of these alterations to the process of ageing are not fully known. The understanding and customtailored modification of these mechanisms are of great clinical importance with regard to disease prevention and modern therapeutic strategies. Here, we aim to summarize the age-related microscopic and molecular changes of the human colon, as well as their role in altered mucosal healing.

Original languageEnglish
Pages (from-to)2981-2986
Number of pages6
JournalWorld Journal of Gastroenterology
Volume17
Issue number25
DOIs
Publication statusPublished - Jul 7 2011

Fingerprint

Regeneration
Colon
Telomere Shortening
Methylation
Intercellular Signaling Peptides and Proteins
Stem Cells
Epithelium
Inflammation
Wounds and Injuries
Genes
Therapeutics

Keywords

  • Ageing
  • Colon
  • Colorectal cancer
  • DNA methylation
  • Mucosal repair
  • Telomere shortening

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of ageing on colonic mucosal regeneration. / Sípos, F.; Leiszter, Katalin; Tulassay, Z.

In: World Journal of Gastroenterology, Vol. 17, No. 25, 07.07.2011, p. 2981-2986.

Research output: Contribution to journalArticle

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