Effect of age on the pharmacokinetics of vinpocetine (Cavinton) and apovincaminic acid

P. Miskolczi, L. Vereczkey, L. Szalay, C. Göndöcs

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The pharmacokinetics of vinpocetine and its main metabolite, apovincaminic acid (AVA), were studied in the aged. Vinpocetine was eliminated with a mean half-life of 2.12±0.51 h. Total plasma clearance (CL) and distribution coefficient (Δ) of the parent drug were 2.2±0.9 l · kg-1 · h-1 and 6.7±3.7 l · kg-1, respectively. The CL and Δ of vinpocetine differed significantly from young subjects but the elimination half-life was not altered. Significant changes in the elimination half-life and plasma clearance of AVA were found, perhaps because of the physiological decrease in renal function.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume33
Issue number2
DOIs
Publication statusPublished - Mar 1 1987

Keywords

  • age effect
  • apovincaminic acid
  • elderly subjects
  • healthy volunteers
  • pharmacokinetics
  • vinpocetine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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