Effect of adenosine on sinoatrial and ventricular automaticity of the guinea pig

A. J. Szentmiklósi, M. Németh, J. Szegi, J. Gy Papp, L. Szekeres

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Abstract

In isolated spontaneously beating right ventricular strips and right atrial preparations of guinea pigs adenosine was found to exert a concentration-dependent suppressing effect on the pacemaker activity. Responsiveness to adenosine was approximately 30-fold higher in ventricular than in atrial preparations. A decrease in the rate of slow diastolic (phase 4) depolarization of Purkinje and sinoatrial nodal fibers proved to be a major determinant of the adenosine-induced alteration in pacemaker activity. It is suggested that adenosine might exert its depressant effect on ventricular automaticity via direct excitation of purine receptors located in the specialized pacemaker fibres of the ventricular tissue.

Original languageEnglish
Pages (from-to)147-149
Number of pages3
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume311
Issue number2
DOIs
Publication statusPublished - Mar 1 1980

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Keywords

  • Adenosine
  • Purine receptors
  • Sinoatrial automaticity
  • Ventricular automaticity

ASJC Scopus subject areas

  • Pharmacology

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