Effect of acute salinomycin-tiamulin toxicity on the lipid peroxide and antioxidant status of broiler chicken.

M. Mézes, G. Sályi, G. Bánhidi, S. Szeberényi

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21 Citations (Scopus)

Abstract

The combined effect, if any, of salinomycin poisoning and salinomycin-tiamulin interaction on lipid-peroxidative processes and the antioxidative defence system of the liver was studied in domestic fowl. Male broilers (28-day-old), reared on a diet containing 60 mg/kg salinomycin, were treated intraoesophageally with salinomycin (140 mg/kg body mass) or tiamulin (50 mg/kg body mass). Malondialdehyde, reduced glutathione and cytochrome P-450 concentrations as well as glutathione peroxidase and catalase activities of the liver were determined. Liver malondialdehyde concentration rose in the salinomycin-treated group while the amount of cytochrome P-450 increased in both groups treated. Glutathione concentration and glutathione peroxidase activity of the liver decreased rapidly but hepatic catalase activity increased in both groups after the treatment. Manifestation of the effect exerted by salinomycin and salinomycin-tiamulin on lipid-peroxidative processes nearly coincided with the onset of clinical signs and preceded the increase of hepatic cytochrome P-450 concentration. According to the results, the background of the previously reported incompatibility between salinomycin and tiamulin is the synergistic effect exerted on the antioxidant (glutathione) system.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalActa Veterinaria Hungarica
Volume40
Issue number4
Publication statusPublished - 1992

Fingerprint

tiamulin
salinomycin
Lipid Peroxides
peroxides
Chickens
Antioxidants
broiler chickens
toxicity
antioxidants
lipids
liver
Liver
cytochrome P-450
Cytochrome P-450 Enzyme System
Glutathione
glutathione
Glutathione Peroxidase
Malondialdehyde
glutathione peroxidase
Catalase

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of acute salinomycin-tiamulin toxicity on the lipid peroxide and antioxidant status of broiler chicken. / Mézes, M.; Sályi, G.; Bánhidi, G.; Szeberényi, S.

In: Acta Veterinaria Hungarica, Vol. 40, No. 4, 1992, p. 251-257.

Research output: Contribution to journalArticle

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