Effect of acute carbon tetrachloride intoxication on the lipid peroxidation and the enzymes of the peroxide metabolism of rat tissues

B. Matkovics, R. Novák, L. Szabó, M. Marik, T. Zsoldos

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Abstract

1. In rats of the same age and strain, maintained under the same conditions, a study was made of how acute CCl4 poisoning effects the peroxide metabolism enzymes (Hyperperoxide dismutase, peroxidase and catalase) of the various tissues, the cytochrome P-450 contents of the liver and kidney microsomes, and the lipid peroxidation of some tissues. 2. At the same time, vitamin E was administered orally to the rats, and a separate study was made of the influence of vitamin E on the above enzymes and tissue components. 3. Carbon tetrachloride and vitamin E were also administered jointly, and a further study was made of their influence on the same components. 4. The results may be briefly summarized in that in all cases the vitamin E pretreatment employed is only able to moderate the acute CCl4 toxicity.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalGeneral Pharmacology
Volume9
Issue number5
DOIs
Publication statusPublished - 1978

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ASJC Scopus subject areas

  • Pharmacology

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