1. In rats of the same age and strain, maintained under the same conditions, a study was made of how acute CCl4 poisoning effects the peroxide metabolism enzymes (Hyperperoxide dismutase, peroxidase and catalase) of the various tissues, the cytochrome P-450 contents of the liver and kidney microsomes, and the lipid peroxidation of some tissues. 2. At the same time, vitamin E was administered orally to the rats, and a separate study was made of the influence of vitamin E on the above enzymes and tissue components. 3. Carbon tetrachloride and vitamin E were also administered jointly, and a further study was made of their influence on the same components. 4. The results may be briefly summarized in that in all cases the vitamin E pretreatment employed is only able to moderate the acute CCl4 toxicity.
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