Effect of ACTH on prostaglandin induced vascular permeability

A. Gecse, A. Ottlecz, M. Farago, T. Forster, G. Telegdy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Increased vascular permeability was induced by prostaglandin E 1 (PGE 1), arachidonic acid and compound 48/80 in male rats. Natural ACTH inhibited Evans blue exudation elicited by arachidonic acid or compound 48/80 in a dose-dependent manner. However, it was ineffective against PGE 1. ACTH(4-10) (d-Phe 7 and l-Phe 7) injected together with the prophlogistic agents depressed the arachidonic acid and compound 48/80 induced vascular reaction. Indomethacin pretreatment inhibited the effect of arachidonic acid on vascular permeability suggesting that arachidonic acid evoked its vascular activity by means of affecting the endogenous synthesis of prostaglandins and, on the other hand, that the prostaglandin system played a role in the vascular permeability inducing effect of compound 48/80. ACTH(4-10) peptide fragments free of steroidogenic action and natural ACTH inhibited locally the in vivo formation of PGs from arachidonic acid in the rat skin, resulting in a nonspecific decrease of local inflammation.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalActa physiologica Academiae Scientiarum Hungaricae
Volume55
Issue number4
Publication statusPublished - Dec 1 1980

ASJC Scopus subject areas

  • Physiology

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