Effect of acidosis and noradrenaline infusion on 14C noradrenaline uptake by the rat myocardium

P. Karpati, I. Preda, E. Endroczi

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Earlier studies revealed that the noradrenaline concentration of myocardial tissue is increased during acidosis. The present findings indicate that the uptake of labelled noradrenaline is less in acidosis. An increased concentration of noradrenaline, on the one hand, and a decrease of the uptake, on the other hand, led us to assume that the hypernoradrenalinaemia occurring during acidosis is basically involved in the contradictory observations. It was found that the infusion of unlabelled noradrenaline (1.5 μg/min for 20 minutes) produced a significant suppression of 14C noradrenaline uptake by both ventricular and atrial tissue. These observations clearly suggested that the decreased noradrenaline uptake during acidosis may be attributed to the substitution of binding sites by endogeneous noradrenaline liberated from extracardial sources.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalActa physiologica Academiae Scientiarum Hungaricae
Issue number1-2
Publication statusPublished - Dec 1 1974

ASJC Scopus subject areas

  • Physiology

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