Effect of acetylsalicylic acid on prostacyclin production in trophoblast

I. Rakoczi, K. Tihanyi, J. Demeter, I. Gati

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In attempt to elucidate whether acetylsalicylic acid (ASA) has an in vivo effect on prostacyclin (PGI2)-like activity released from trophoblast we have evaluated PGI2-like activity in pregnant women scheduled for pregnancy termination after ASA ingestion. The following subjects were studied: Group I: 7 healthy pregnant women who were treated with 1.5 g ASA for two days; Group II: 18 control pregnant women who received placebo for two days. Trophoblast specimens were obtained by legal abortions; PGI2-like activity in trophoblast was measured by the method of Moncada. In normal pregnant women (8-10 weeks gestation) treated with ASA the mean PGI2-like activity of trophoblast significantly decreased compared to the controls. These data indicate that treatment with ASA of early pregnant women might have a harmful effect on trophoblast and the problem should be further explored before allowing the administration of cyclooxygenase inhibiting drugs during early pregnancy.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalActa Physiologica Hungarica
Volume65
Issue number3
Publication statusPublished - 1985

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Trophoblasts
Epoprostenol
Aspirin
Pregnant Women
Pregnancy
Legal Abortion
Prostaglandin-Endoperoxide Synthases
Eating
Placebos
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of acetylsalicylic acid on prostacyclin production in trophoblast. / Rakoczi, I.; Tihanyi, K.; Demeter, J.; Gati, I.

In: Acta Physiologica Hungarica, Vol. 65, No. 3, 1985, p. 379-382.

Research output: Contribution to journalArticle

Rakoczi, I. ; Tihanyi, K. ; Demeter, J. ; Gati, I. / Effect of acetylsalicylic acid on prostacyclin production in trophoblast. In: Acta Physiologica Hungarica. 1985 ; Vol. 65, No. 3. pp. 379-382.
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