Effect of a water-soluble corticosteroid analogue in experimental hemorrhagic shock

Sandor Nagy, Klara Tarnoky, Gabor Petri

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The effect of 11β, 17α-dihydroxy-3,-20-dioxo 21-N (N′-methylpiperazinyl) 1,4-pregnadien hydrochloride, a water-soluble corticosteroid analogue, was investigated in hemorrhagic shock in dogs. In a dose of 15 mg./kg. the steroid raised considerably the blood pressure of the oligemic animals, improved their survival rate and decreased some metabolic changes characteristic of shock. In a dose of 7.5 mg./kg. the above effects were less; a dose of 1.5 mg./kg. does not significantly alter the course of the shock.

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalJournal of Surgical Research
Issue number2
Publication statusPublished - Feb 1964


ASJC Scopus subject areas

  • Surgery

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