Effect of a single neonatal oxytocin treatment (hormonal imprinting) on the biogenic amine level of the adult rat brain

Could oxytocin-induced labor cause pervasive developmental diseases?

F. Hashemi, K. Tekes, R. Laufer, P. Szegi, L. Tóthfalusi, G. Csaba

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Perinatal single-hormone treatment causes hormonal imprinting with lifelong consequences in receptor-binding capacity, hormone production as well as in social and sexual behavior. In the present experiments, newborn rats were treated with a single dose of oxytocin, and the levels of biogenic amines and their metabolites were studied in 8 different brain regions and in the sera when the male and female animals were 4 months old. Both dopaminergic and serotonergic neurotransmission was found to be significantly influenced. The levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole acetic acid metabolites decreased in the hypothalamus and striatum. Dopamine, serotonin, norepinephrine, and 5-hydroxytryptophol levels were hardly altered, and there was no difference in the epinephrine levels. The results show that dopamine and serotonin metabolism of hypothalamus and striatum are deeply and lifelong influenced by a single neonatal oxytocin treatment Oxytocin imprinting resulted in decreased dopamine turnover in the hypothalamus and decreased serotonin turnover in the hypothalamus, medulla oblongata, and striatum of females. As the disturbance of brain dopamine and serotonin system has an important role in the development of pervasive developmental diseases (eg, autism) and neuropsychiatric disorders (eg, schizophrenia), the growing number of oxytocin-induced labor as a causal factor, cannot be omitted.

Original languageEnglish
Pages (from-to)1255-1263
Number of pages9
JournalReproductive Sciences
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Induced Labor
Biogenic Amines
Oxytocin
Hypothalamus
Dopamine
Serotonin
Brain
Hydroxytryptophol
Hormones
3,4-Dihydroxyphenylacetic Acid
Homovanillic Acid
Medulla Oblongata
Social Behavior
Autistic Disorder
Synaptic Transmission
Acetic Acid
Sexual Behavior
Epinephrine
Schizophrenia
Norepinephrine

Keywords

  • autism
  • hormonal imprinting
  • neonatal treatments
  • oxytocin
  • parturition

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

@article{8437945aaa35495baa7baf1b1f4cb5f6,
title = "Effect of a single neonatal oxytocin treatment (hormonal imprinting) on the biogenic amine level of the adult rat brain: Could oxytocin-induced labor cause pervasive developmental diseases?",
abstract = "Perinatal single-hormone treatment causes hormonal imprinting with lifelong consequences in receptor-binding capacity, hormone production as well as in social and sexual behavior. In the present experiments, newborn rats were treated with a single dose of oxytocin, and the levels of biogenic amines and their metabolites were studied in 8 different brain regions and in the sera when the male and female animals were 4 months old. Both dopaminergic and serotonergic neurotransmission was found to be significantly influenced. The levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole acetic acid metabolites decreased in the hypothalamus and striatum. Dopamine, serotonin, norepinephrine, and 5-hydroxytryptophol levels were hardly altered, and there was no difference in the epinephrine levels. The results show that dopamine and serotonin metabolism of hypothalamus and striatum are deeply and lifelong influenced by a single neonatal oxytocin treatment Oxytocin imprinting resulted in decreased dopamine turnover in the hypothalamus and decreased serotonin turnover in the hypothalamus, medulla oblongata, and striatum of females. As the disturbance of brain dopamine and serotonin system has an important role in the development of pervasive developmental diseases (eg, autism) and neuropsychiatric disorders (eg, schizophrenia), the growing number of oxytocin-induced labor as a causal factor, cannot be omitted.",
keywords = "autism, hormonal imprinting, neonatal treatments, oxytocin, parturition",
author = "F. Hashemi and K. Tekes and R. Laufer and P. Szegi and L. T{\'o}thfalusi and G. Csaba",
year = "2013",
month = "10",
doi = "10.1177/1933719113483010",
language = "English",
volume = "20",
pages = "1255--1263",
journal = "Reproductive Sciences",
issn = "1933-7191",
publisher = "SAGE Publications Inc.",
number = "10",

}

TY - JOUR

T1 - Effect of a single neonatal oxytocin treatment (hormonal imprinting) on the biogenic amine level of the adult rat brain

T2 - Could oxytocin-induced labor cause pervasive developmental diseases?

AU - Hashemi, F.

AU - Tekes, K.

AU - Laufer, R.

AU - Szegi, P.

AU - Tóthfalusi, L.

AU - Csaba, G.

PY - 2013/10

Y1 - 2013/10

N2 - Perinatal single-hormone treatment causes hormonal imprinting with lifelong consequences in receptor-binding capacity, hormone production as well as in social and sexual behavior. In the present experiments, newborn rats were treated with a single dose of oxytocin, and the levels of biogenic amines and their metabolites were studied in 8 different brain regions and in the sera when the male and female animals were 4 months old. Both dopaminergic and serotonergic neurotransmission was found to be significantly influenced. The levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole acetic acid metabolites decreased in the hypothalamus and striatum. Dopamine, serotonin, norepinephrine, and 5-hydroxytryptophol levels were hardly altered, and there was no difference in the epinephrine levels. The results show that dopamine and serotonin metabolism of hypothalamus and striatum are deeply and lifelong influenced by a single neonatal oxytocin treatment Oxytocin imprinting resulted in decreased dopamine turnover in the hypothalamus and decreased serotonin turnover in the hypothalamus, medulla oblongata, and striatum of females. As the disturbance of brain dopamine and serotonin system has an important role in the development of pervasive developmental diseases (eg, autism) and neuropsychiatric disorders (eg, schizophrenia), the growing number of oxytocin-induced labor as a causal factor, cannot be omitted.

AB - Perinatal single-hormone treatment causes hormonal imprinting with lifelong consequences in receptor-binding capacity, hormone production as well as in social and sexual behavior. In the present experiments, newborn rats were treated with a single dose of oxytocin, and the levels of biogenic amines and their metabolites were studied in 8 different brain regions and in the sera when the male and female animals were 4 months old. Both dopaminergic and serotonergic neurotransmission was found to be significantly influenced. The levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole acetic acid metabolites decreased in the hypothalamus and striatum. Dopamine, serotonin, norepinephrine, and 5-hydroxytryptophol levels were hardly altered, and there was no difference in the epinephrine levels. The results show that dopamine and serotonin metabolism of hypothalamus and striatum are deeply and lifelong influenced by a single neonatal oxytocin treatment Oxytocin imprinting resulted in decreased dopamine turnover in the hypothalamus and decreased serotonin turnover in the hypothalamus, medulla oblongata, and striatum of females. As the disturbance of brain dopamine and serotonin system has an important role in the development of pervasive developmental diseases (eg, autism) and neuropsychiatric disorders (eg, schizophrenia), the growing number of oxytocin-induced labor as a causal factor, cannot be omitted.

KW - autism

KW - hormonal imprinting

KW - neonatal treatments

KW - oxytocin

KW - parturition

UR - http://www.scopus.com/inward/record.url?scp=84872837527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872837527&partnerID=8YFLogxK

U2 - 10.1177/1933719113483010

DO - 10.1177/1933719113483010

M3 - Article

VL - 20

SP - 1255

EP - 1263

JO - Reproductive Sciences

JF - Reproductive Sciences

SN - 1933-7191

IS - 10

ER -