Effect of a plant-originated natural compound, CoD™ extract, on c-myc, Ha-ras and p53 gene expression in short-term animal experiments

E. Nádasi, I. Prantner, T. Dávid, I. Ember

Research output: Contribution to journalArticle

Abstract

Several plant-originated natural compounds were shown to exhibit chemopreventive effect in carcinogenesis. In our studies, we have investigated CoD extract, a complex plant extract made from several tropical plants with possible cancer preventive effect in animal experiments. c-myc, p53 and Ha-ras gene expressions were investigated 24, 48 and 72 h after CoD extract and dimethylbenz(a)-anthracene (DMBA) treatment in CBA/Ca(H-2K) mice. CoD extract administered together with DMBA diminished c-myc, p53 and Ha-ras gene expressions both in the 24 and 48 h experiments, but not in the 72 h experiments. Further in vivo and human studies are needed to clarify the possible role of CoD extract in the prevention of tumour formation after carcinogenic exposures.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalActa Alimentaria
Volume37
Issue number1
DOIs
Publication statusPublished - Mar 2008

Fingerprint

9,10-Dimethyl-1,2-benzanthracene
ras Genes
animal experimentation
p53 Genes
Gene Expression
gene expression
Plant Extracts
extracts
Complex Mixtures
Neoplasms
Carcinogenesis
neoplasms
plant extracts
carcinogenesis
mice
anthracene

Keywords

  • "Short-term" studies
  • Anticarcinogenic effect
  • CoD™ extract
  • Gene expression
  • Plant-originated natural compounds

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Effect of a plant-originated natural compound, CoD™ extract, on c-myc, Ha-ras and p53 gene expression in short-term animal experiments. / Nádasi, E.; Prantner, I.; Dávid, T.; Ember, I.

In: Acta Alimentaria, Vol. 37, No. 1, 03.2008, p. 87-92.

Research output: Contribution to journalArticle

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