Effect of a new bifunctional nitrosoureido derivative on human colorectal tumor xenografts

L. Kopper, K. Lapis, E. Csanyi, T. Horvath

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2 Citations (Scopus)

Abstract

The tumor inhibiting effect of a newly developed bifunctional nitrosoureido derivative (GYKI-13324) was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalAnticancer research
Volume1
Issue number4
Publication statusPublished - Dec 1 1981

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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