Effect of a kynurenic acid analog on home-cage activity and body temperature in rats

Ferenc Kassai, Rita Kedves, István Gyertyán, Bernadett Tuka, F. Fülöp, J. Toldi, Balázs Lendvai, L. Vécsei

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background N-(2-N,N-Dimethylaminoethyl)-4-oxo-1H-quinoline-2-carboxamide hydrochloride (SzR-72) is a kynurenic acid (KYNA) amide analog that displays neuroprotective action. Whereas its brain penetration ability and its solubility limit the therapeutic use of KYNA: the corresponding properties of the analog exceed those of the parent compound. Although SzR-72 has been extensively studied, its exact mechanism of action has not yet been fully clarified. As KYNA induces hypothermia in laboratory rodents, it may be hypothesized that SzR-72 may have a similar effect. This would be of major importance, since the hypothermia generated by external cooling is neuroprotective, thus a putative hypothermic effect of SzR-72 could contribute to its neuroprotective action. Methods The effects of SzR-72 on the body temperature and home-cage activity of rats were studied by using a telemetry system. In order to follow the longitudinal changes in the effects of the compound, subchronic drug administration was applied. Results The initial administration of the compound induced substantial hypothermia and reduced the home-cage activity. During the 5 days of SzR-72 administration, partial tolerance developed to the hypothermic effect, while the inhibition of home-cage activity detected after the acute administration was completely tolerated. Conclusions On the basis of these results, it cannot be excluded that the hypothermic effect of SzR-72 contributes to its neuroprotective action.

Original languageEnglish
Pages (from-to)1188-1192
Number of pages5
JournalPharmacological Reports
Volume67
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Kynurenic Acid
Body Temperature
Hypothermia
Induced Hypothermia
Telemetry
Therapeutic Uses
Amides
Solubility
Rodentia
Brain
Pharmaceutical Preparations

Keywords

  • Home-cage activity
  • Hypothermia
  • Kynurenic acid
  • Kynurenic acid analog
  • Telemetry

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of a kynurenic acid analog on home-cage activity and body temperature in rats. / Kassai, Ferenc; Kedves, Rita; Gyertyán, István; Tuka, Bernadett; Fülöp, F.; Toldi, J.; Lendvai, Balázs; Vécsei, L.

In: Pharmacological Reports, Vol. 67, No. 6, 01.12.2015, p. 1188-1192.

Research output: Contribution to journalArticle

Kassai, Ferenc ; Kedves, Rita ; Gyertyán, István ; Tuka, Bernadett ; Fülöp, F. ; Toldi, J. ; Lendvai, Balázs ; Vécsei, L. / Effect of a kynurenic acid analog on home-cage activity and body temperature in rats. In: Pharmacological Reports. 2015 ; Vol. 67, No. 6. pp. 1188-1192.
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AU - Tuka, Bernadett

AU - Fülöp, F.

AU - Toldi, J.

AU - Lendvai, Balázs

AU - Vécsei, L.

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