Effect of a cholinesterase inhibitor treatment on the phosphorus and nucleic acid metabolism in the stomach wall

G. Mózsik, B. Kiss, T. Jávor, M. Krausz, E. Tóth

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8 Citations (Scopus)

Abstract

The stomach wall was analysed biochemically in rats treated with neostigmine. The biochemical extraction of different phosphorus components and nucleic acids was carried out according to Schneitler-Schmidt-Thannhauser's method. The acid-soluble inorganic phosphates, phospholipid phosphates, acid-soluble organic phosphates, ribonucleic acidic phosphates, deoxyribonucleic acidic phosphates, pentose (in ribonucleic acid) and deoxyribose (in deoxyribonucleic acid) were measured speclrometrically. The author's conclusions are the following: (1) The cholinergic dominance of the autonomic nerves involves different biochemical changes in the glandular and membranaceous stomach wall. (2) After a chronic cholinesterase inhibitor treatment 'short-term' and 'long-term' biochemical changes can be observed in the glandular stomach wall. (3) Vagotomy and neostigmine treatment resulted in some respects in similar changes in the biochemistry of the stomach wall (acid-soluble inorganic phosphates, phospholipid phosphates, ribonucleic acid). (4) The biochemical alterations in the stomach wall are not identical in the membranaceous and glandular stomach wall from the viewpoint of vagus nerve function.

Original languageEnglish
Pages (from-to)45-59
Number of pages15
JournalPharmacology
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 1 1969

ASJC Scopus subject areas

  • Pharmacology

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