Effect of 5,7-dihydroxytryptamine on the food-aversive conditioning in the snail Helix lucorum L

Pavel M. Balaban, A. Vehovszky, Olga A. Maximova, Igor S. Zakharov

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The effects of 5,7-dihydroxytryptamine (5,7-DHT), a drug which selectively ablates serotonergic terminals, were examined on acquisition of food-aversive conditioned reflex in the snail Helix lucorum. The percent of feeding reactions decreased from 80 to 15% in the conditioned group of animals after 5-8 pairings of food and electric shock. The behavioral performance of 5,7-DHT-injected animals after the same training session coincided with the data received from the unpaired control group: the percent of feeding reactions remained the same as before the training. Conditioning was carried out on the semi-intact 'lip-CNS' preparations as well. Intracellular recordings from the neurons responding to the withdrawal reaction confirmed the results of the behavioral experiments. Elaboration of associative changes was effective on preparations made from normal snails, whereas no changes were noted in 5,7-DHT-treated and pseudoconditioned animals. In 5,7-DHT-treated animals some components of the feeding behavior and withdrawal reaction changed as well. The appetitive phase duration of feeding lengthened significantly, moreover the sensitization of the withdrawal reaction evoked by rhythimic tactile stimulation disappeared in preparations made frmo drug-treated snails.

Original languageEnglish
Pages (from-to)201-210
Number of pages10
JournalBrain Research
Volume404
Issue number1-2
DOIs
Publication statusPublished - Feb 24 1987

Fingerprint

Helix (Snails)
5,7-Dihydroxytryptamine
Food
Snails
Classical Conditioning
Touch
Feeding Behavior
Lip
Pharmaceutical Preparations
Shock
Neurons
Control Groups
Conditioning (Psychology)

Keywords

  • 'Lip-CNS' preparation
  • 5,7,-Dihydroxytryptamine
  • Aversive conditioning
  • Feeding behaviour
  • Intracellular recording

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effect of 5,7-dihydroxytryptamine on the food-aversive conditioning in the snail Helix lucorum L. / Balaban, Pavel M.; Vehovszky, A.; Maximova, Olga A.; Zakharov, Igor S.

In: Brain Research, Vol. 404, No. 1-2, 24.02.1987, p. 201-210.

Research output: Contribution to journalArticle

Balaban, Pavel M. ; Vehovszky, A. ; Maximova, Olga A. ; Zakharov, Igor S. / Effect of 5,7-dihydroxytryptamine on the food-aversive conditioning in the snail Helix lucorum L. In: Brain Research. 1987 ; Vol. 404, No. 1-2. pp. 201-210.
@article{29656eada10f495cba80ad771e3e6b3b,
title = "Effect of 5,7-dihydroxytryptamine on the food-aversive conditioning in the snail Helix lucorum L",
abstract = "The effects of 5,7-dihydroxytryptamine (5,7-DHT), a drug which selectively ablates serotonergic terminals, were examined on acquisition of food-aversive conditioned reflex in the snail Helix lucorum. The percent of feeding reactions decreased from 80 to 15{\%} in the conditioned group of animals after 5-8 pairings of food and electric shock. The behavioral performance of 5,7-DHT-injected animals after the same training session coincided with the data received from the unpaired control group: the percent of feeding reactions remained the same as before the training. Conditioning was carried out on the semi-intact 'lip-CNS' preparations as well. Intracellular recordings from the neurons responding to the withdrawal reaction confirmed the results of the behavioral experiments. Elaboration of associative changes was effective on preparations made from normal snails, whereas no changes were noted in 5,7-DHT-treated and pseudoconditioned animals. In 5,7-DHT-treated animals some components of the feeding behavior and withdrawal reaction changed as well. The appetitive phase duration of feeding lengthened significantly, moreover the sensitization of the withdrawal reaction evoked by rhythimic tactile stimulation disappeared in preparations made frmo drug-treated snails.",
keywords = "'Lip-CNS' preparation, 5,7,-Dihydroxytryptamine, Aversive conditioning, Feeding behaviour, Intracellular recording",
author = "Balaban, {Pavel M.} and A. Vehovszky and Maximova, {Olga A.} and Zakharov, {Igor S.}",
year = "1987",
month = "2",
day = "24",
doi = "10.1016/0006-8993(87)91371-0",
language = "English",
volume = "404",
pages = "201--210",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Effect of 5,7-dihydroxytryptamine on the food-aversive conditioning in the snail Helix lucorum L

AU - Balaban, Pavel M.

AU - Vehovszky, A.

AU - Maximova, Olga A.

AU - Zakharov, Igor S.

PY - 1987/2/24

Y1 - 1987/2/24

N2 - The effects of 5,7-dihydroxytryptamine (5,7-DHT), a drug which selectively ablates serotonergic terminals, were examined on acquisition of food-aversive conditioned reflex in the snail Helix lucorum. The percent of feeding reactions decreased from 80 to 15% in the conditioned group of animals after 5-8 pairings of food and electric shock. The behavioral performance of 5,7-DHT-injected animals after the same training session coincided with the data received from the unpaired control group: the percent of feeding reactions remained the same as before the training. Conditioning was carried out on the semi-intact 'lip-CNS' preparations as well. Intracellular recordings from the neurons responding to the withdrawal reaction confirmed the results of the behavioral experiments. Elaboration of associative changes was effective on preparations made from normal snails, whereas no changes were noted in 5,7-DHT-treated and pseudoconditioned animals. In 5,7-DHT-treated animals some components of the feeding behavior and withdrawal reaction changed as well. The appetitive phase duration of feeding lengthened significantly, moreover the sensitization of the withdrawal reaction evoked by rhythimic tactile stimulation disappeared in preparations made frmo drug-treated snails.

AB - The effects of 5,7-dihydroxytryptamine (5,7-DHT), a drug which selectively ablates serotonergic terminals, were examined on acquisition of food-aversive conditioned reflex in the snail Helix lucorum. The percent of feeding reactions decreased from 80 to 15% in the conditioned group of animals after 5-8 pairings of food and electric shock. The behavioral performance of 5,7-DHT-injected animals after the same training session coincided with the data received from the unpaired control group: the percent of feeding reactions remained the same as before the training. Conditioning was carried out on the semi-intact 'lip-CNS' preparations as well. Intracellular recordings from the neurons responding to the withdrawal reaction confirmed the results of the behavioral experiments. Elaboration of associative changes was effective on preparations made from normal snails, whereas no changes were noted in 5,7-DHT-treated and pseudoconditioned animals. In 5,7-DHT-treated animals some components of the feeding behavior and withdrawal reaction changed as well. The appetitive phase duration of feeding lengthened significantly, moreover the sensitization of the withdrawal reaction evoked by rhythimic tactile stimulation disappeared in preparations made frmo drug-treated snails.

KW - 'Lip-CNS' preparation

KW - 5,7,-Dihydroxytryptamine

KW - Aversive conditioning

KW - Feeding behaviour

KW - Intracellular recording

UR - http://www.scopus.com/inward/record.url?scp=0023141271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023141271&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(87)91371-0

DO - 10.1016/0006-8993(87)91371-0

M3 - Article

C2 - 3567566

AN - SCOPUS:0023141271

VL - 404

SP - 201

EP - 210

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -