Effect of 5-HT1C and 5-HT2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations

G. Bagdy, Konstantine T. Kalogeras, Katalin Szemeredi

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Serotonin (5-HT) receptor agonist-induced excessive grooming, penile erection and oxytocin secretion were studied in chronically cannulated freely moving rats. The 5-HT1C receptor agonists, m-chlorophenylpiperazine (m-CPP), which also binds to other 5-HT receptors, produced dose-dependent excessive grooming, penile erection and increases in circulating oxytocin concentrations. Maximal responses for excessive grooming and penile erection occured at 0.3-0.6 mg/kg i.v. m-CPP. Higher doses (0.9-2.5 mg/kg i.v.) caused further increases in oxytocin concentrations, but attenuated both behavioral responses. All three responses to m-CPP (0.6 mg/kg) were attenuated by antagonist with high affinity for the 5-HT1C receptor site (mianserin, LY-53857 and metergoline), but not by the 5-HT2 receptor antagonist ketanserin. The 5-HT2/5-HT1C agonist, 1-(2,5-dimenthoxy-4-iodophenyl)-2-aminopropane (DOI), increased plasma oxytocin concentrations only. After katanserin pretreatment, DOI caused penile erection and diminished the oxytocin response. All responses to DOI were blocked completely by pretreatment with LY-53857 plus ketanserin. Excessive grooming and penile erection showed significant bimodal correlations with the oxytocin response. These data suggest that stimulation of 5-HT1C receptors induces excessive grooming, penile erection and increased oxytocin secretion. Stimulation of 5-HT2 receptors causes a further increase in plasma oxytocin concentration, but inhibits both behavioral responses.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalEuropean Journal of Pharmacology
Volume229
Issue number1
DOIs
Publication statusPublished - Dec 8 1992

Fingerprint

Penile Erection
Grooming
Oxytocin
LY 53857
Ketanserin
Serotonin Receptors
Metergoline
Serotonin 5-HT2 Receptor Agonists
Mianserin
Serotonin 5-HT2 Receptor Antagonists
Serotonin Receptor Agonists
serotonin 1C receptor

Keywords

  • 5-HT (5-hydroxytryptamine, serotonin)
  • 5-HT receptors
  • 5-HT receptors
  • DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane)
  • Excessive grooming
  • m-CPP (1-(3-chrlorophenyl)piperazine)
  • Oxytocin concentration (plasma)
  • Penile erection

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effect of 5-HT1C and 5-HT2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations. / Bagdy, G.; Kalogeras, Konstantine T.; Szemeredi, Katalin.

In: European Journal of Pharmacology, Vol. 229, No. 1, 08.12.1992, p. 9-14.

Research output: Contribution to journalArticle

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AB - Serotonin (5-HT) receptor agonist-induced excessive grooming, penile erection and oxytocin secretion were studied in chronically cannulated freely moving rats. The 5-HT1C receptor agonists, m-chlorophenylpiperazine (m-CPP), which also binds to other 5-HT receptors, produced dose-dependent excessive grooming, penile erection and increases in circulating oxytocin concentrations. Maximal responses for excessive grooming and penile erection occured at 0.3-0.6 mg/kg i.v. m-CPP. Higher doses (0.9-2.5 mg/kg i.v.) caused further increases in oxytocin concentrations, but attenuated both behavioral responses. All three responses to m-CPP (0.6 mg/kg) were attenuated by antagonist with high affinity for the 5-HT1C receptor site (mianserin, LY-53857 and metergoline), but not by the 5-HT2 receptor antagonist ketanserin. The 5-HT2/5-HT1C agonist, 1-(2,5-dimenthoxy-4-iodophenyl)-2-aminopropane (DOI), increased plasma oxytocin concentrations only. After katanserin pretreatment, DOI caused penile erection and diminished the oxytocin response. All responses to DOI were blocked completely by pretreatment with LY-53857 plus ketanserin. Excessive grooming and penile erection showed significant bimodal correlations with the oxytocin response. These data suggest that stimulation of 5-HT1C receptors induces excessive grooming, penile erection and increased oxytocin secretion. Stimulation of 5-HT2 receptors causes a further increase in plasma oxytocin concentration, but inhibits both behavioral responses.

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