Effect of 5, 6-dihydroxytryptamine on the structure of nerve fibres in the chronically isolated cat ileum

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The structure ofthe nerve fibres in the chronically isolated cat ileum was studied by fluorescence and electron microscopy after 5, 6-dihydroxytryptamine (5, 6-DHT) treatment. Residual fluorescence rapidly disappears after administration of 5, 6-DHT. Under the electron microscope, degeneration of most of the nerve processes containing a special population of 120-to 140-nm diameter granular vesicles could be observed. Also the degeneration of presynaptic terminals in the local ganglia was observed frequently. Some degenerating nerve fibres were found in the inner muscular layer, in the connective tissue surrounding Lieberkiihn’s glands, and in the stroma of the villi. The axons (and/or other nerve processes) undergoing degeneration are assumed to belong to the serotoninergic neurons ofthe local ganglia. A substantial number of nerve cell processes remaining intact after 5, 6-DHT treatment contain different population of vesicles: either 30-to 60-nm agranular and 100-to 120-nm granular vesicles or 30-to 60-nm agranular and 160-to 200-nm diameter neurosecretory type vesicles.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalCells Tissues Organs
Volume98
Issue number1
DOIs
Publication statusPublished - Jan 1 1977

Keywords

  • 6-Dihydroxytryptamine
  • Cat
  • Effect of 5
  • Small intestine

ASJC Scopus subject areas

  • Anatomy
  • Histology

Fingerprint Dive into the research topics of 'Effect of 5, 6-dihydroxytryptamine on the structure of nerve fibres in the chronically isolated cat ileum'. Together they form a unique fingerprint.

  • Cite this