Effect of 3-amino-1-propanol on the phosphatidylinositol (PI) and glycosyl phosphatidylinositol (GPI) systems of Tetrahymena

P. Kovács, L. Kőhidai, G. Csaba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

3-Amino-1-propanol (AP), a substance replacing ethanolamine in phosphatidylethanolamine (PE) significantly reduced 32P incorporation to phosphatidylinositol (PI) and glycosyl-phosphatidylinositol (GPI) in the unicellular organism Tetrahymena pyriformis. At 10 mM, AP completely inhibited the incorporation of 32P into PI. 3H-arachidonate incorporation into PI was also inhibited, while that into diacylglycerol (DAG) was high. The experiments indicate the presence and metabolism of inositol phospholipids and GPI in T. pyriformis.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalComparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
Volume118
Issue number1
DOIs
Publication statusPublished - Sep 1997

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Tetrahymena
Glycosylphosphatidylinositols
Phosphatidylinositols
Tetrahymena pyriformis
Ethanolamine
Diglycerides
3-amino-1-propanol

Keywords

  • GPI
  • Phosphoinositol metabolism
  • PI
  • Signaling
  • Tetrahymena

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

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abstract = "3-Amino-1-propanol (AP), a substance replacing ethanolamine in phosphatidylethanolamine (PE) significantly reduced 32P incorporation to phosphatidylinositol (PI) and glycosyl-phosphatidylinositol (GPI) in the unicellular organism Tetrahymena pyriformis. At 10 mM, AP completely inhibited the incorporation of 32P into PI. 3H-arachidonate incorporation into PI was also inhibited, while that into diacylglycerol (DAG) was high. The experiments indicate the presence and metabolism of inositol phospholipids and GPI in T. pyriformis.",
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T1 - Effect of 3-amino-1-propanol on the phosphatidylinositol (PI) and glycosyl phosphatidylinositol (GPI) systems of Tetrahymena

AU - Kovács, P.

AU - Kőhidai, L.

AU - Csaba, G.

PY - 1997/9

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N2 - 3-Amino-1-propanol (AP), a substance replacing ethanolamine in phosphatidylethanolamine (PE) significantly reduced 32P incorporation to phosphatidylinositol (PI) and glycosyl-phosphatidylinositol (GPI) in the unicellular organism Tetrahymena pyriformis. At 10 mM, AP completely inhibited the incorporation of 32P into PI. 3H-arachidonate incorporation into PI was also inhibited, while that into diacylglycerol (DAG) was high. The experiments indicate the presence and metabolism of inositol phospholipids and GPI in T. pyriformis.

AB - 3-Amino-1-propanol (AP), a substance replacing ethanolamine in phosphatidylethanolamine (PE) significantly reduced 32P incorporation to phosphatidylinositol (PI) and glycosyl-phosphatidylinositol (GPI) in the unicellular organism Tetrahymena pyriformis. At 10 mM, AP completely inhibited the incorporation of 32P into PI. 3H-arachidonate incorporation into PI was also inhibited, while that into diacylglycerol (DAG) was high. The experiments indicate the presence and metabolism of inositol phospholipids and GPI in T. pyriformis.

KW - GPI

KW - Phosphoinositol metabolism

KW - PI

KW - Signaling

KW - Tetrahymena

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