Effect of 3-amino-1-propanol, indomethacin and 4-bromophenacyl bromide on the hormone binding of insulin pretreated Tetrahymena

influence of phospholipid metabolism disturbances on hormonal imprinting.

P. Kovács, G. Csaba

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The compound 3-amino-1-propanol which replaces ethanolamine in phosphatidyl-ethanolamine and inhibits transformation of it, hindered insulin imprinting of Tetrahymena. Indomethacin, an inhibitor of prostaglandin synthesis and arachidonate metabolism provoked negative imprinting. 4-Bromophenacyl bromide, a phospholipase A2 inhibitor, hindered imprintability by insulin. Immediately after treatment these substances inhibited insulin binding. The experiment calls attention to the importance of intactness of metabolic pathways and second messenger systems in the mechanism of imprinting.

Original languageEnglish
Pages (from-to)255-261
Number of pages7
JournalMicrobios
Volume84
Issue number341
Publication statusPublished - 1995

Fingerprint

Tetrahymena
Indomethacin
Phospholipids
Ethanolamine
Hormones
Insulin
Prostaglandin Antagonists
Second Messenger Systems
Metabolic Networks and Pathways
3-amino-1-propanol
4-bromophenacyl bromide

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

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abstract = "The compound 3-amino-1-propanol which replaces ethanolamine in phosphatidyl-ethanolamine and inhibits transformation of it, hindered insulin imprinting of Tetrahymena. Indomethacin, an inhibitor of prostaglandin synthesis and arachidonate metabolism provoked negative imprinting. 4-Bromophenacyl bromide, a phospholipase A2 inhibitor, hindered imprintability by insulin. Immediately after treatment these substances inhibited insulin binding. The experiment calls attention to the importance of intactness of metabolic pathways and second messenger systems in the mechanism of imprinting.",
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AU - Csaba, G.

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AB - The compound 3-amino-1-propanol which replaces ethanolamine in phosphatidyl-ethanolamine and inhibits transformation of it, hindered insulin imprinting of Tetrahymena. Indomethacin, an inhibitor of prostaglandin synthesis and arachidonate metabolism provoked negative imprinting. 4-Bromophenacyl bromide, a phospholipase A2 inhibitor, hindered imprintability by insulin. Immediately after treatment these substances inhibited insulin binding. The experiment calls attention to the importance of intactness of metabolic pathways and second messenger systems in the mechanism of imprinting.

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