The effect of mitolactol (DBD) on S37 ascites tumor cells was examined by electron microscope autoradiography. In mice treated with DBD intraperitoneally, the intracellular distribution of the radioactivity in the tumor cells was changed 120 min after the administration of 3H uridine, viz. the nucleolar activity was lower, the cytoplasmic activity was higher than in the controls; 48 hr after DBD treatment the nuclear radioactive concentration (r.c.) was lower than in the controls; the cytoplasmic r.c. was higher than in the controls, irrespective of the interval (6, 24 or 48 hr) between DBD treatment and the injection of the radioactive precursor. It is supposed that some damage in the nuclear membrane or a disturbed metabolism of substances participating in the RNA transport might be responsible for the changes.
|Number of pages||5|
|Journal||Acta biologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1973|
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)