Effect of 12-o-tetradecanoylphorbol-13-acetate on polyamine metabolism in mice sensitive and resistant to lung-adenoma

Susan Bardócz, P. Rády, I. Ember, T. Karsai, P. Kertai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Ornithine decarboxylase activity and polyamine concentrations were determined in the lungs of mice from 0 to 20 h after treatment with 12-O-tetradecanoylphorbol-13-acetate (17.7 nmol in 0.2 ml acetone/mouse). In CFLP mice, which responded to carcinogen with development of lung-adenomas, a single topical application of TPA to hairless mouse skin increased ornithine decarboxylase activity in the lung. In contrast, in C3H/He-mg mouse strain, which were resistant to lung-adenoma production, TPA application did not increase ODC activity of the lungs.

Original languageEnglish
Pages (from-to)1349-1350
Number of pages2
JournalCarcinogenesis
Volume4
Issue number10
DOIs
Publication statusPublished - Oct 1 1983

ASJC Scopus subject areas

  • Cancer Research

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