Effect of β-sitosterol on the characteristics of vesicular gels containing chlorhexidine

E. Farkas, R. Schubert, R. Zelkó

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Previous studies confirm that β-sitosterol is very effective in altering the molecular packing of soybean lecithin bilayers even more than the cholesterol. The primary aim of the present study was to evaluate the influence of the β-sitosterol portion in the lipid bilayer on the physical-chemical characteristics of the prepared gel systems, and its influence on the consequent drug release from the liposomes obtained from vesicular phospholipid gels (VPG-s) by redispersion. VPG-s were prepared of different molar ratios of lecithin:sterol components (10:90-35:65 mol%). The mixture was hydrated with the aqueous solution of chlorhexidin digluconate in order to achieve 30% (w/w) final concentration of the lipid mixtures and 4% (w/w) concentration of the drug in each homogenized VPG sample. To characterize the obtained VPG systems optical microscopic examinations using polarized light, differential scanning calorimetry (DSC), photon correlation spectroscopy (PCS), and dynamic surface tension measurements were carried out. Vertical type diffusion cell was applied to determine the amount of released chlorhexidine digluconate. As a result of the surface tension-decreasing effect of β-sitosterol, the membrane deformability and the dispersity of the system increased. The increased dispersity and fluidity significantly increased the extent of released chlorhexidine from the vesicles.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume278
Issue number1
DOIs
Publication statusPublished - Jun 18 2004

Fingerprint

Chlorhexidine
Surface Tension
Lecithins
Gels
Phospholipids
Optical Devices
Differential Scanning Calorimetry
Lipid Bilayers
Sterols
Photons
Soybeans
Liposomes
Spectrum Analysis
Cholesterol
Lipids
Light
Membranes
Pharmaceutical Preparations
gamma-sitosterol

Keywords

  • β-Sitosterol
  • Chlorhexidine digluconate release
  • Dispersity
  • Dynamic surface tension
  • Vesicular phospholipid gels (VPG)

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Effect of β-sitosterol on the characteristics of vesicular gels containing chlorhexidine. / Farkas, E.; Schubert, R.; Zelkó, R.

In: International Journal of Pharmaceutics, Vol. 278, No. 1, 18.06.2004, p. 63-70.

Research output: Contribution to journalArticle

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