EEG predicts surgical outcome in lesional frontal lobe epilepsy

J. Janszky, H. Jokeit, R. Schulz, M. Hoppe, Alois Ebner

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Background: Because of the relatively poor results of frontal lobe epilepsy (FLE) surgery, identification of prognostic factors for surgical outcome is of great importance. Methods: To identify predictive factors for FLE surgery, we analyzed the data of 61 patients (mean age at surgery 19.2) who had undergone presurgical evaluation and resective surgery in the frontal lobe. Postoperative follow-up ranged from 0.5 to 5 years (mean 1.78). Fifty- nine patients had MRI-detectable lesions. Histopathologic examination showed dysplasia (57.4%), tumor (16.4%), or other lesions (26.2%). Thirty postoperatively seizure-free patients were compared with 31 non-seizure-free patients with respect to clinical history, seizure semiology, EEG and neuroimaging data, resected area, and postoperative data including histopathology. Results: Three preoperative and two postoperative variables were related to poor outcome: generalized epileptiform discharges, generalized slowing, use of intracranial electrodes, incomplete resection detected by MRI, and postoperative epileptiform discharges. The only preoperative factor associated with seizure-free outcome was the absence of generalized EEG signs. Multivariate analysis showed that only the absence of generalized EEG signs predicts the outcome independently. Moreover, the occurrence of a somatosensory aura, secondarily generalized seizures, and negative MRI was identified as additional independent risk factors for poor surgical results. Conclusions: The absence of generalized EEG signs is the most predictive variable for a seizure-free outcome in FLE surgery. Furthermore, nonlesional MRI, somatosensory aura, and secondarily generalized seizures are risk factors for poor surgical results.

Original languageEnglish
Pages (from-to)1470-1476
Number of pages7
JournalNeurology
Volume54
Issue number7
Publication statusPublished - Apr 11 2000

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Frontal Lobe Epilepsy
Electroencephalography
Seizures
Epilepsy
Frontal Lobe
Neuroimaging
Electrodes
Multivariate Analysis

Keywords

  • EEG
  • Epilepsy surgery
  • Frontal lobe
  • MRI
  • Multivariate analysis
  • Prognosis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Janszky, J., Jokeit, H., Schulz, R., Hoppe, M., & Ebner, A. (2000). EEG predicts surgical outcome in lesional frontal lobe epilepsy. Neurology, 54(7), 1470-1476.

EEG predicts surgical outcome in lesional frontal lobe epilepsy. / Janszky, J.; Jokeit, H.; Schulz, R.; Hoppe, M.; Ebner, Alois.

In: Neurology, Vol. 54, No. 7, 11.04.2000, p. 1470-1476.

Research output: Contribution to journalArticle

Janszky, J, Jokeit, H, Schulz, R, Hoppe, M & Ebner, A 2000, 'EEG predicts surgical outcome in lesional frontal lobe epilepsy', Neurology, vol. 54, no. 7, pp. 1470-1476.
Janszky J, Jokeit H, Schulz R, Hoppe M, Ebner A. EEG predicts surgical outcome in lesional frontal lobe epilepsy. Neurology. 2000 Apr 11;54(7):1470-1476.
Janszky, J. ; Jokeit, H. ; Schulz, R. ; Hoppe, M. ; Ebner, Alois. / EEG predicts surgical outcome in lesional frontal lobe epilepsy. In: Neurology. 2000 ; Vol. 54, No. 7. pp. 1470-1476.
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