EEG network connectivity changes in mild cognitive impairment - Preliminary results

Brigitta Tóth, Bálint File, Roland Boha, Zsófia Kardos, Zoltán Hidasi, Zsófia Anna Gaál, Éva Csibri, Pál Salacz, Cornelis Jan Stam, M. Molnár

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Resting state EEGs were compared between patients with amnestic subtype of mild cognitive impairment (aMCI) and matched elderly controls at two times over a one year period. The study aimed at investigating the role of functional connectivity between and within different brain regions in relation to the progression of cognitive deficit in MCI. The EEG was recorded in two sessions during eyes closed and eyes open resting conditions. Functional brain connectivity was investigated based on the measurement of phase synchronization in different frequency bands. Delta and theta synchronization characteristics indicated decreased level of local and large-scale connectivity in the patients within the frontal, between the frontal and temporal, and frontal and parietal brain areas which was more pronounced 1. year later. As a consequence of opening the eyes connectivity in the alpha1 band within the parietal lobe decreased compared to the eyes closed condition but only in the control group. The lack of alpha1 band reactivity following eye opening could reliably differentiate patients from controls. Our preliminary results support the notion that the functional disconnection between distant brain areas is a characteristic feature of MCI, and may prove to be predictive in terms of the progression of this condition.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Psychophysiology
Volume92
Issue number1
DOIs
Publication statusPublished - Apr 2014

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Electroencephalography
Brain
Parietal Lobe
Cognitive Dysfunction
Control Groups

Keywords

  • EEG
  • Follow-up study
  • Functional connectivity
  • Mild cognitive impairment
  • Phase synchronization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)
  • Neuropsychology and Physiological Psychology

Cite this

EEG network connectivity changes in mild cognitive impairment - Preliminary results. / Tóth, Brigitta; File, Bálint; Boha, Roland; Kardos, Zsófia; Hidasi, Zoltán; Gaál, Zsófia Anna; Csibri, Éva; Salacz, Pál; Stam, Cornelis Jan; Molnár, M.

In: International Journal of Psychophysiology, Vol. 92, No. 1, 04.2014, p. 1-7.

Research output: Contribution to journalArticle

Tóth, B, File, B, Boha, R, Kardos, Z, Hidasi, Z, Gaál, ZA, Csibri, É, Salacz, P, Stam, CJ & Molnár, M 2014, 'EEG network connectivity changes in mild cognitive impairment - Preliminary results', International Journal of Psychophysiology, vol. 92, no. 1, pp. 1-7. https://doi.org/10.1016/j.ijpsycho.2014.02.001
Tóth, Brigitta ; File, Bálint ; Boha, Roland ; Kardos, Zsófia ; Hidasi, Zoltán ; Gaál, Zsófia Anna ; Csibri, Éva ; Salacz, Pál ; Stam, Cornelis Jan ; Molnár, M. / EEG network connectivity changes in mild cognitive impairment - Preliminary results. In: International Journal of Psychophysiology. 2014 ; Vol. 92, No. 1. pp. 1-7.
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