EEG effect of orexin a in freely moving rats

Attila Toth, B. Balatoni, T. Hajnik, L. Détári

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Orexin A and orexin B are neuropeptides produced by a group of neurons located in the lateral hypothalamus which send widespread projections virtually to the whole neuraxis. Several studies indicated that orexins play a crucial role in the sleep-wake regulation and in the pathomechanism of the sleep disorder narcolepsy. As no data are available related to the EEG effects of orexin A in healthy, freely moving rats, the aim of the present experiments was to analyze EEG power changes in the generally used frequency bands after intracerebroventricular orexin A administration.Orexin A administration (0.84 and 2.8 nM/rat) differently affected fronto-occipital EEG waves in the different frequency bands recorded for 24 hours. Delta (1-4 Hz) and alpha (10-16 Hz) power decreased, while theta (4-10 Hz) and beta (16-48 Hz) power increased. Decrease of the delta power was followed by a rebound in case of the higher orexin A dose. This complex picture might be explained by the activation of several systems by the orexin A administration. Among these systems, cortical and thalamic circuits as well as the role of the neurons containing corticotrophin-releasing factor might be of significant importance.

Original languageEnglish
Pages (from-to)332-343
Number of pages12
JournalActa Physiologica Hungarica
Volume99
Issue number3
DOIs
Publication statusPublished - Sep 1 2012

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Electroencephalography
Lateral Hypothalamic Area
Neurons
Narcolepsy
Orexins
Corticotropin-Releasing Hormone
Neuropeptides
Sleep
Power (Psychology)

Keywords

  • cortical activation
  • delta power
  • EEG
  • freely moving rats
  • orexin A
  • rebound
  • sleep
  • slow cortical rhythm

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

EEG effect of orexin a in freely moving rats. / Toth, Attila; Balatoni, B.; Hajnik, T.; Détári, L.

In: Acta Physiologica Hungarica, Vol. 99, No. 3, 01.09.2012, p. 332-343.

Research output: Contribution to journalArticle

Toth, Attila ; Balatoni, B. ; Hajnik, T. ; Détári, L. / EEG effect of orexin a in freely moving rats. In: Acta Physiologica Hungarica. 2012 ; Vol. 99, No. 3. pp. 332-343.
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