Economic approach to robotic sample pretreatment in high-performance liquid chromatography

Antal Tolokán, Lajos Gödörházy, V. Horváth, Andrea Hrabéczy-Páll, Zsuzsanna Niegreisz, Emilia Kocsi, G. Horvai, I. Klebovich, Katalin Balogh-Nemes

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Economic automation of multistep analytical sample preparation is still a largely unsolved problem. Existing systems either handle only a few steps of a complex analytical scheme or they offer a complete solution at relatively high cost. This paper shows, using a rather general example that it is possible to construct a system in the analytical laboratory with an optimal balance between automating most steps of the analysis scheme and still keeping the costs of the system within bounds. A practical example from pharmacokinetic analysis is presented; pretreatment of blood plasma samples for nifedipine determination by high-performance liquid chromatography. The automated method involves steps such as aliquoting, pH adjustment, liquid-liquid extraction and evaporation to dryness. The system is built around a robotic arm from commercial equipment not designed originally for use with a robot. Analytical results and costs are compared to the manual method.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalJournal of Chromatography A
Volume771
Issue number1-2
DOIs
Publication statusPublished - May 30 1997

Fingerprint

High performance liquid chromatography
Robotics
High Pressure Liquid Chromatography
Economics
Costs and Cost Analysis
Costs
Robotic arms
Liquid-Liquid Extraction
Pharmacokinetics
Automation
Liquids
Nifedipine
Evaporation
Blood
Robots
Plasmas
Equipment and Supplies

Keywords

  • Automation
  • Nifedipine
  • Sample handling

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Tolokán, A., Gödörházy, L., Horváth, V., Hrabéczy-Páll, A., Niegreisz, Z., Kocsi, E., ... Balogh-Nemes, K. (1997). Economic approach to robotic sample pretreatment in high-performance liquid chromatography. Journal of Chromatography A, 771(1-2), 35-43. https://doi.org/10.1016/S0021-9673(97)00186-6

Economic approach to robotic sample pretreatment in high-performance liquid chromatography. / Tolokán, Antal; Gödörházy, Lajos; Horváth, V.; Hrabéczy-Páll, Andrea; Niegreisz, Zsuzsanna; Kocsi, Emilia; Horvai, G.; Klebovich, I.; Balogh-Nemes, Katalin.

In: Journal of Chromatography A, Vol. 771, No. 1-2, 30.05.1997, p. 35-43.

Research output: Contribution to journalArticle

Tolokán, Antal ; Gödörházy, Lajos ; Horváth, V. ; Hrabéczy-Páll, Andrea ; Niegreisz, Zsuzsanna ; Kocsi, Emilia ; Horvai, G. ; Klebovich, I. ; Balogh-Nemes, Katalin. / Economic approach to robotic sample pretreatment in high-performance liquid chromatography. In: Journal of Chromatography A. 1997 ; Vol. 771, No. 1-2. pp. 35-43.
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