Eco-friendly syntheses of 2,2-disubstituted- and 2-spiroquinazolinones

Ferenc Miklós, Veronika Hum, Ferenc Fülöp

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Environmentally friendly methods were applied to prepare quinazolin-4(1H)-one derivatives in either aqueous or solventless medium from anthranilamide and a number of ketones. With dialkyl-substituted ketones, acetophenone and cycloalkanones, the ring closure proceeded smoothly under either aqueous or solventless conditions. With poorly water-soluble cycloalkanones, the ring closure was carried out under mechanochemical ball-milling conditions, in the presence of molecular iodine as catalyst. The environmentally friendly protocols applied resulted in the corresponding quinazolinones in quantitative yields.

Original languageEnglish
Pages (from-to)25-37
Number of pages13
JournalArkivoc
Volume2014
Issue number6
DOIs
Publication statusPublished - Oct 1 2014

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Keywords

  • Aqueous
  • Ball-milling reactions
  • Environmentally friendly methods
  • Mechanochemical
  • Solventless

ASJC Scopus subject areas

  • Organic Chemistry

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