Ekdiszteroidok a Silene italica ssp. nemoralis-ból, az ekdiszteroidok felhasználásának néhány új lehetosége

Translated title of the contribution: Ecdysteroids of Silene italica ssp. nemoralis, novel approaches of ecdysteroid therapy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ecdysteroids are known as insect moulting hormones. They have the basic steroid structure, although their physiological effects on mammalians do not show the thymolytic and androgenic side effects of vertebrate type steroid hormones. At the same time, phytoecdysteroids can be used utilizing their anabolic and adaptogenic effects. Ecdysteroids also have a tremendous potential in the most modern therapy. Recently, the biotechnology started to employ ecdysteroids as powerful inducers for gene-switch systems with insertion of modified insect receptor into the malignant cells. Nineteen ecdysteroids were isolated with combined Chromatographic methods from the herbs of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman. The chemical structure of the isolated compounds have been elucidated using spectroscopic methods (x-ray, UV, CD, IR, MS, 1D-, 2D-NMR, HMQC, HMBC, COSY, TOCSY, NOESY, ROESY). Structural determination of two of the five new ecdysteroids is detailed here.

Translated title of the contributionEcdysteroids of Silene italica ssp. nemoralis, novel approaches of ecdysteroid therapy
Original languageHungarian
Pages (from-to)131-141
Number of pages11
JournalActa pharmaceutica Hungarica
Volume74
Issue number3
Publication statusPublished - Oct 25 2004

ASJC Scopus subject areas

  • Pharmaceutical Science

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