Ekdiszteroidok a Silene italica ssp. nemoralis-ból, az ekdiszteroidok felhasználásának néhány új lehetosége

Translated title of the contribution: Ecdysteroids of Silene italica ssp. nemoralis, novel approaches of ecdysteroid therapy

M. Báthori, A. Kálmán, Gábor Tóth, G. Argay, A. Simon, A. Gergely, Zita Pongrácz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ecdysteroids are known as insect moulting hormones. They have the basic steroid structure, although their physiological effects on mammalians do not show the thymolytic and androgenic side effects of vertebrate type steroid hormones. At the same time, phytoecdysteroids can be used utilizing their anabolic and adaptogenic effects. Ecdysteroids also have a tremendous potential in the most modern therapy. Recently, the biotechnology started to employ ecdysteroids as powerful inducers for gene-switch systems with insertion of modified insect receptor into the malignant cells. Nineteen ecdysteroids were isolated with combined Chromatographic methods from the herbs of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman. The chemical structure of the isolated compounds have been elucidated using spectroscopic methods (x-ray, UV, CD, IR, MS, 1D-, 2D-NMR, HMQC, HMBC, COSY, TOCSY, NOESY, ROESY). Structural determination of two of the five new ecdysteroids is detailed here.

Original languageHungarian
Pages (from-to)131-141
Number of pages11
JournalActa Pharmaceutica Hungarica
Volume74
Issue number3
Publication statusPublished - 2004

Fingerprint

Silene
Ecdysteroids
Insect Hormones
Steroids
Switch Genes
Ecdysone
Therapeutics
Anabolic Agents
Biotechnology
Insects
Vertebrates
X-Rays
Hormones

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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title = "Ekdiszteroidok a Silene italica ssp. nemoralis-b{\'o}l, az ekdiszteroidok felhaszn{\'a}l{\'a}s{\'a}nak n{\'e}h{\'a}ny {\'u}j lehetos{\'e}ge",
abstract = "Ecdysteroids are known as insect moulting hormones. They have the basic steroid structure, although their physiological effects on mammalians do not show the thymolytic and androgenic side effects of vertebrate type steroid hormones. At the same time, phytoecdysteroids can be used utilizing their anabolic and adaptogenic effects. Ecdysteroids also have a tremendous potential in the most modern therapy. Recently, the biotechnology started to employ ecdysteroids as powerful inducers for gene-switch systems with insertion of modified insect receptor into the malignant cells. Nineteen ecdysteroids were isolated with combined Chromatographic methods from the herbs of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman. The chemical structure of the isolated compounds have been elucidated using spectroscopic methods (x-ray, UV, CD, IR, MS, 1D-, 2D-NMR, HMQC, HMBC, COSY, TOCSY, NOESY, ROESY). Structural determination of two of the five new ecdysteroids is detailed here.",
author = "M. B{\'a}thori and A. K{\'a}lm{\'a}n and G{\'a}bor T{\'o}th and G. Argay and A. Simon and A. Gergely and Zita Pongr{\'a}cz",
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AU - Báthori, M.

AU - Kálmán, A.

AU - Tóth, Gábor

AU - Argay, G.

AU - Simon, A.

AU - Gergely, A.

AU - Pongrácz, Zita

PY - 2004

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AB - Ecdysteroids are known as insect moulting hormones. They have the basic steroid structure, although their physiological effects on mammalians do not show the thymolytic and androgenic side effects of vertebrate type steroid hormones. At the same time, phytoecdysteroids can be used utilizing their anabolic and adaptogenic effects. Ecdysteroids also have a tremendous potential in the most modern therapy. Recently, the biotechnology started to employ ecdysteroids as powerful inducers for gene-switch systems with insertion of modified insect receptor into the malignant cells. Nineteen ecdysteroids were isolated with combined Chromatographic methods from the herbs of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman. The chemical structure of the isolated compounds have been elucidated using spectroscopic methods (x-ray, UV, CD, IR, MS, 1D-, 2D-NMR, HMQC, HMBC, COSY, TOCSY, NOESY, ROESY). Structural determination of two of the five new ecdysteroids is detailed here.

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