Early renal function recovery and long-term graft survival in kidney transplantation

Susan S. Wan, Marcelo Cantarovich, I. Mucsi, Dana Baran, Steven Paraskevas, Jean Tchervenkov

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Abstract

Following kidney transplantation (KTx), renal function improves gradually until a baseline eGFR is achieved. Whether or not a recipient achieves the best-predicted eGFR after KTx may have important implications for immediate patient management, as well as for long-term graft survival. The aim of this cohort study was to calculate the renal function recovery (RFR) based on recipient and donor eGFR and to evaluate the association between RFR and long-term death-censored graft failure (DCGF). We studied 790 KTx recipients between January 1990 and August 2014. The last donor SCr prior to organ procurement was used to estimate donor GFR. Recipient eGFR was calculated using the average of the best three SCr values observed during the first 3 months post-KTx. RFR was defined as the ratio of recipient eGFR to half the donor eGFR. 53% of recipients had an RFR ≥1. There were 127 death-censored graft failures (16%). Recipients with an RFR ≥1 had less DCGF compared with those with an RFR

Original languageEnglish
Pages (from-to)619-626
Number of pages8
JournalTransplant International
Volume29
Issue number5
DOIs
Publication statusPublished - May 1 2016

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Keywords

  • estimated glomerular filtration rate
  • graft survival
  • renal function
  • renal function recovery
  • serum creatinine

ASJC Scopus subject areas

  • Transplantation

Cite this

Wan, S. S., Cantarovich, M., Mucsi, I., Baran, D., Paraskevas, S., & Tchervenkov, J. (2016). Early renal function recovery and long-term graft survival in kidney transplantation. Transplant International, 29(5), 619-626. https://doi.org/10.1111/tri.12775