Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency

Mirjana Kovac, Gorana Mitic, Milos Jesic, Valentina Djordjevic, L. Muszbek, Z. Bereczky

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The overall incidence of thromboembolic events in the neonatal period is 5 per 100?000 births, wherein more than 40% of all such manifestations are symptomatic renal vein thromboses. We describe the case of a newborn female who developed extensive thrombosis, which filled the inferior vena cava and renal vein and was diagnosed in the first weeks of life. A homozygous type II heparin-binding site antithrombin deficiency (c. 391C>T, p. Leu131Phe) was detected in the background. Despite the timely diagnosis and appropriate treatment, clinical signs of renal insufficiency, because of left kidney atrophy and arterial hypertension, were observed. Our case demonstrates the seriousness of the consequences arising after early onset of venous thrombosis caused by homozygous type II heparin-binding site antithrombin deficiency. In addition to prompt diagnosis, of huge importance is the determination of inherited thrombophilia, as it significantly affects therapeutic treatment and indicates that long-term follow-up is mandatory.

Original languageEnglish
JournalBlood Coagulation and Fibrinolysis
DOIs
Publication statusAccepted/In press - May 20 2016

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Renal Veins
Antithrombins
Venous Thrombosis
Heparin
Thrombosis
Binding Sites
Thrombophilia
Inferior Vena Cava
Atrophy
Renal Insufficiency
Parturition
Hypertension
Kidney
Incidence
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency. / Kovac, Mirjana; Mitic, Gorana; Jesic, Milos; Djordjevic, Valentina; Muszbek, L.; Bereczky, Z.

In: Blood Coagulation and Fibrinolysis, 20.05.2016.

Research output: Contribution to journalArticle

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