Early-onset carotid atherosclerosis is associated with increased intima-media thickness and elevated serum levels of inflammatory markers

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Abstract

Background and Purpose - Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients <55 years of age. Methods - Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with > 30% stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound. Results - White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (P

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalStroke
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

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Carotid Artery Diseases
Serum
Lipoprotein(a)
Carotid Stenosis
Leukocyte Count
Carotid Arteries
C-Reactive Protein
Fibrinogen
Atherosclerosis
Pathologic Constriction

Keywords

  • Atherosclerosis
  • Homocyst(e)ine
  • Inflammation
  • Intima-media thickness
  • Lipid peroxidation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

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abstract = "Background and Purpose - Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients <55 years of age. Methods - Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with > 30{\%} stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound. Results - White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (P",
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author = "M. Magyar and Z. Szikszai and J. Balla and A. Valikovics and J. Kappelmayer and S{\'a}ndor Imre and G. Balla and V. Jeney and L. Csiba and D. Bereczki",
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T1 - Early-onset carotid atherosclerosis is associated with increased intima-media thickness and elevated serum levels of inflammatory markers

AU - Magyar, M.

AU - Szikszai, Z.

AU - Balla, J.

AU - Valikovics, A.

AU - Kappelmayer, J.

AU - Imre, Sándor

AU - Balla, G.

AU - Jeney, V.

AU - Csiba, L.

AU - Bereczki, D.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Background and Purpose - Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients <55 years of age. Methods - Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with > 30% stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound. Results - White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (P

AB - Background and Purpose - Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients <55 years of age. Methods - Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with > 30% stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound. Results - White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (P

KW - Atherosclerosis

KW - Homocyst(e)ine

KW - Inflammation

KW - Intima-media thickness

KW - Lipid peroxidation

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