Early micro-rheological consequences of single fraction total body low-dose photon irradiation in mice

Kornelia Szluha, Kornelia Lazanyi, Andrea Furka, Ferenc Kiss, Imre Szabo, Eva Pintye, I. Mikó, N. Németh

Research output: Contribution to journalArticle

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Abstract

Despite of the studies on widespread biological effects of irradiation, surprisingly only little number of papers can be found dealing with its in vivo hemorheological impact. Furthermore, other studies suggested that low-dose irradiation might differ from high-dose in more than linear ways. On Balb/c Jackson female adult mice hematological and hemorheological impacts of total body irradiation were investigated 1 hour following 0.002, 0.005, 0.01, 0.02, 0.05 and 0.1 Gy dose irradiation. In case of 0.01 Gy further groups were analyzed 30 minutes, 2, 4, 6, 24 and 48 h after irradiation. According to the results, it seems that the dose-dependent changes of blood micro-rheological parameters are not linear. The irradiation dose of 0.01 Gy acted as a point of 'inflexion', because by this dose we found the most expressed changes in hematological parameters, as well as in red blood cell aggregation, deformability and osmoscan data. The time-dependent changes showed progressive decrease in pH, rise in lactate concentration, further decrease in erythrocyte aggregation index and deformability, with moderate shifting of the optimal osmolarity point and modulation in membrane stability. As conclusion, low-dose total body irradiation may cause micro-rheological changes, being non-linearly correlated with the irradiation dose.

Original languageEnglish
Pages (from-to)227-242
Number of pages16
JournalClinical Hemorheology and Microcirculation
Volume57
Issue number3
DOIs
Publication statusPublished - 2014

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Whole-Body Irradiation
Photons
Erythrocyte Aggregation
Erythrocyte Deformability
Cell Aggregation
Erythrocyte Indices
Osmolar Concentration
Lactic Acid
Erythrocytes
Membranes

Keywords

  • low-dose irradiation
  • mice
  • osmotic gradient ektacytometry
  • red blood cell aggregation
  • Red blood cell deformability

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Early micro-rheological consequences of single fraction total body low-dose photon irradiation in mice. / Szluha, Kornelia; Lazanyi, Kornelia; Furka, Andrea; Kiss, Ferenc; Szabo, Imre; Pintye, Eva; Mikó, I.; Németh, N.

In: Clinical Hemorheology and Microcirculation, Vol. 57, No. 3, 2014, p. 227-242.

Research output: Contribution to journalArticle

Szluha, Kornelia ; Lazanyi, Kornelia ; Furka, Andrea ; Kiss, Ferenc ; Szabo, Imre ; Pintye, Eva ; Mikó, I. ; Németh, N. / Early micro-rheological consequences of single fraction total body low-dose photon irradiation in mice. In: Clinical Hemorheology and Microcirculation. 2014 ; Vol. 57, No. 3. pp. 227-242.
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